PMID: 11606169Oct 19, 2001Paper

The effect of acute hyperglycaemia on appetite and food intake in Type 1 diabetes mellitus

Diabetic Medicine : a Journal of the British Diabetic Association
A W RussellIan M Chapman

Abstract

To determine the effects of acute hyperglycaemia on appetite and food intake in Type 1 diabetes mellitus. Two separate studies, each involving eight adults with uncomplicated Type 1 diabetes, were performed: one in the fasted state (A) and the other after a nutrient preload (B). In both studies, perceptions of appetite (hunger and fullness) and food intake at a buffet meal were evaluated during euglycaemia (blood glucose, approximately 6 mmol/l) and hyperglycaemia (blood glucose, approximately 14 mmol/l). Both experiments were randomized and single-blind. In study A, appetite was assessed in the fasted state for 90 min before the buffet meal. In study B, a nutrient 'preload' of Ensure and milk containing 13C-octanoic acid was consumed 90 min before the meal. Gastric emptying of the preload was quantified with a radioisotopic breath test technique. There was no significant difference in plasma insulin concentrations between euglycaemia and hyperglycaemia in either study. In study A, there were no differences in hunger, fullness or energy intake between the two treatment days. In study B, subjects were slightly less hungry between the preload and buffet meal during hyperglycaemia than euglycaemia (P = 0.04), and tended to have sl...Continue Reading

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Citations

May 8, 2002·Diabetes/metabolism Research and Reviews
Jan 4, 2013·PloS One·Darleen SandovalRandy J Seeley
Jan 12, 2010·Physiology & Behavior·Richard D Mattes
May 24, 2008·Physiology & Behavior·Fiona McKiernanRichard D Mattes
Sep 28, 2004·Diabetes·Barry E LevinAmbrose A Dunn-Meynell
Nov 25, 2005·Diabetes Care·Bernd SchultesWerner Kern
Sep 17, 2008·European Journal of Gastroenterology & Hepatology·Carolyn QuanMichael Horowitz
Jul 20, 2011·Nature Reviews. Gastroenterology & Hepatology·William L Hasler
Aug 24, 2004·The American Journal of Clinical Nutrition·Kerstin SturmMichael Horowitz

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