PMID: 9553994Apr 29, 1998Paper

The effect of acute lithium and rubidium pretreatment on apomorphine-induced pecking in pigeons

Pharmacology & Toxicology
A R DehpourM A Chavoushzadeh

Abstract

The effects of different doses of lithium (5-320 mg/kg intramuscularly) and rubidium (0.25 32 mg/kg intramuscularly) on apomorphine-induced pecking were investigated in pigeons. These two cations did not induce pecking by itself. Intramuscular administration of apomorphine (a mixed D1/D2 dopamine receptors agonist, 0.1-1.6 mg/kg) induced pecking in a dose-dependent manner. SCH 23390 (D1 dopamine receptor antagonist, 0.02-0.08 mg/kg) and sulpiride (D2 dopamine receptor antagonist, 25-100 mg/kg) decreased apomorphine-induced pecking dose-dependently. Combination of SCH 23390 (0.04 mg/kg) with sulpiride (50 mg/kg) caused a stronger inhibitory effect on apomorphine response. This indicates that both D1 and D2 dopamine receptors are involved in apomorphine-induced pecking. The response induced by apomorphine (0.2-0.8 mg/kg) was decreased in animals pretreated with lithium and rubidium. In these conditions, SCH 23390 and sulpiride produced a larger inhibitory effect on the apomorphine response, suggesting that acute lithium and rubidium pretreatment inhibit pecking by interfering with dopaminergic mechanisms.

References

Jan 11, 1979·Nature·J W Kebabian, D B Calne
Jan 1, 1992·Psychopharmacology·M R Zarrindast, R Amin
Aug 1, 1992·Brain Research Bulletin·V A Dorce, J Palermo-Neto
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·P M CarveyH L Klawans
Aug 1, 1987·Psychological Medicine·A J Wood, G M Goodwin
Jan 1, 1988·Psychopharmacology·D M JacksonS B Ross
Mar 26, 1985·European Journal of Pharmacology·A Dumbrille-RossP Seeman
Nov 19, 1986·European Journal of Pharmacology·A R Braun, T N Chase
Feb 5, 1985·European Journal of Pharmacology·T M DawsonJ K Wamsley
Jan 1, 1973·The American Journal of Psychiatry·R R FieveA Thomas
May 1, 1974·European Journal of Pharmacology·H C Cheng, J P Long
Jun 1, 1968·Journal of Psychiatric Research·M Schou
Apr 23, 1982·European Journal of Pharmacology·K S KendlerK L Davis
Jan 1, 1983·Annual Review of Neuroscience·I CreeseS E Leff
Dec 3, 1984·Life Sciences·J C Stoof, J W Kebabian
Sep 1, 1995·General Pharmacology·A R DehpourH Hasan-Mazandarani
Jan 1, 1996·Journal of Psychopharmacology·M SharifzadehG R Asghari

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Citations

Aug 27, 1999·Progress in Neurobiology·D DurstewitzO Güntürkün
Nov 13, 2002·Pharmacology & Toxicology·Soheila Fazli-TabaeiMohammad-Reza Zarrindast

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