PMID: 11903956Mar 21, 2002Paper

The effect of acute oxidative stress on the ultrastructure of the perfused rat liver

Pharmacology & Toxicology
Victoria C CoggerDavid G Le Couteur

Abstract

Ageing and liver disease are associated with ultrastructural changes in the hepatic sinusoid. Because of the possibility that reactive oxygen species could mediate these processes, we examined the effect of acute oxidative stress on the ultrastructure of the intact liver. Rat livers were perfused ex vivo, in situ with hydrogen peroxide via the portal vein. The livers were then fixed and the ultrastructure of the liver tissue examined with transmission and scanning electron microscopy. The effects of hydrogen peroxide were largely confined to the perisinusoidal areas. The sinusoidal endothelial cells became swollen and more porous, with large gaps replacing sieve plates. The space of Disse showed an increase in volume and the density of hepatocyte projections decreased. Kupffer cell activation was noted. Little or no ultrastructural change was observed within the hepatocytes. Oxidative stress delivered via the portal vein dramatically alters the ultrastructure of the perisinusoidal regions of the liver. This process may contribute to the pathogenesis of disease and age-related changes in the liver.

Citations

Jun 6, 2002·Lancet·David G Le CouteurAllan J McLean
Feb 1, 2003·Experimental Gerontology·Gary R AndrewsDavid G Le Couteur
Oct 2, 2009·Clinical and Experimental Pharmacology & Physiology·Tharani SabaretnamLeonard Kritharides
Aug 30, 2008·World Journal of Gastroenterology : WJG·Ilker TasciBilgin Comert
Jan 1, 2013·Computational and Structural Biotechnology Journal·Victoria C CoggerDavid G Le Couteur
Sep 2, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Tharani SabaretnamDavid G Le Couteur
Mar 14, 2008·Experimental Gerontology·Alessandra StacchiottiLuigi Fabrizio Rodella
Jul 31, 2007·Experimental Gerontology·Rajkumar CheluvappaDavid G Le Couteur
Jan 6, 2007·Experimental Gerontology·Hamish A JamiesonDavid G Le Couteur
Nov 28, 2006·Journal of Hepatology·Alessandra WarrenDavid G Le Couteur
Jan 13, 2009·International Journal of Experimental Pathology·Rajkumar CheluvappaSarah N Hilmer
Apr 13, 2011·Fundamental & Clinical Pharmacology·S IlavenilS Ravikumar
Dec 17, 2009·Pathology·Rajkumar CheluvappaDavid G Le Couteur
Sep 1, 2004·Journal of Hepatology·Victoria C CoggerDavid G Le Couteur
Aug 28, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Mark L BassettAllan J McLean
Aug 17, 2005·Experimental Gerontology·Douglas L Schmucker
Jul 9, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rajkumar CheluvappaDavid G Le Couteur
May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vadanasundari VedarethinamYoung Ock Kim
Oct 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alessandra WarrenPatrick Bertolino
Jun 1, 2004·Pharmacological Reviews·Allan J McLean, David G Le Couteur

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