The effect of acute pain crisis on exhaled nitric oxide levels in children with sickle cell disease

Pediatric Blood & Cancer
Sachin S PawarDavid C Brousseau

Abstract

Exhaled nitric oxide (FE(NO)) has been shown to be decreased in children with sickle cell disease. We sought to evaluate the effect of sickle cell vaso-occlusive crisis (VOC) on FE(NO) levels. We measured FE(NO) levels in 42 children with sickle cell disease, 29 in their baseline health and 13 during an acute VOC. There was no difference in FE(NO) levels between children at baseline (15.12 +/- 9.32 ppb) and those during an acute VOC (15.68 +/- 7.26 ppb; P = 0.794). FE(NO) is not a useful marker of acute VOC in children with sickle cell disease.

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Citations

Apr 15, 2011·Anemia·Kathryn Blake, John Lima
Dec 17, 2009·Hematology·Joshua J Field, Michael R DeBaun
Aug 16, 2016·The Journal of Allergy and Clinical Immunology·Robyn T CohenRobert C Strunk
Aug 21, 2010·Journal of Pediatric Hematology/oncology·Kevin Joseph SullivanSuzanne Murphy

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