The effect of adenosine triphosphate on sevoflurane requirements for minimum alveolar anesthetic concentration and minimum alveolar anesthetic concentration-awake

Anesthesia and Analgesia
A SuzukiK Ikeda

Abstract

We evaluated the effects of i.v. adenosine triphosphate (ATP) on sevoflurane minimum alveolar anesthetic concentration (MAC) and MAC-Awake. The study group included healthy patients 20-60 yr of age. The study groups for MAC-Awake determination included 49 patients who were scheduled for elective surgery. The study groups for MAC determination included 53 patients scheduled for elective surgery involving a skin incision. These patients were randomly assigned to two groups, an ATP group and a control group. The ATP group received 100 micrograms.kg-1.min-1 ATP i.v., and the control group received no medication. The ATP group and the control group were compared with regard to MAC-Awake (anesthetic concentration achieving 50% probability of eye opening in response to a verbal command) and MAC (anesthetic concentration achieving 50% probability of no movement in response to skin incision). The MAC-Awake was 0.7% +/- 0.1% in the control group (mean +/- SD) and 0.7% +/- 0.1% in the ATP group. MAC was 1.9% +/- 0.1% in the control group and 2.1% +/- 0.2% in the ATP group. The differences in MAC and MAC-Awake between the two groups were not statistically significant. We conclude that ATP infusion (100 micrograms.kg-1.min-1) has no effect ...Continue Reading

References

Oct 1, 1976·British Journal of Anaesthesia·Y Tanifuji, E I Eger
Jan 1, 1989·Neuroscience·J Sawynok, M I Sweeney
Mar 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M S SchellerB L Partridge
Oct 1, 1984·Anesthesiology·A SolleviC Lindquist
Aug 1, 1995·Acta Anaesthesiologica Scandinavica·A EkblomA Sollevi

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Citations

Aug 21, 2008·Anesthesia and Analgesia·Edmond I EgerJames M Sonner
Mar 31, 2015·The Surgical Clinics of North America·Lisa L SchlitzkusPaul J Schenarts
Nov 9, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Wei-Nung TengChien-Kun Ting
May 1, 2002·Anesthesiology·James Sonner, Dennis M Fisher
Oct 3, 2002·Journal of Neurosurgical Anesthesiology·Gina MateiIra S Kass

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