The effect of adenotonsillectomy on ventilatory control in children with obstructive sleep apnea

Sleep
Keren Armoni DomanyRaouf S Amin

Abstract

The contribution of ventilatory control to the pathogenesis of obstructive sleep apnea (OSA) in children and the effect of adenotonsillectomy are unknown. We aimed to examine the difference in ventilatory control between children with OSA and those without OSA. We also examined the effect of adenotonsillectomy on parameters of ventilatory control. Healthy children with OSA and matched controls were recruited. Polysomnography was performed before adenotonsillectomy in the OSA group and 6 months postoperatively. Controls underwent the same assessment at the two time points. Loop gain (LG), controller gain (CG), and plant gain (PG), which reflect the stability of ventilatory control, chemoreceptor sensitivity and the pulmonary control of blood gas in response to a change in ventilation, respectively, were estimated from polysomnographic tracings which included spontaneous sighs and tracings with tidal breathing. A linear mixed model was used to examine the changes of the ventilatory control parameters from baseline to 6 months. Ninety-nine children aged 7-13 were recruited to the study. Fifty-three with OSA and 46 controls. At baseline, compared with controls, children with OSA had higher PG and lower CG. LG did not differ between...Continue Reading

References

Jan 1, 1989·Annals of Biomedical Engineering·M C Khoo, V Z Marmarelis
Sep 1, 1988·Gynecologic Oncology·C J Cohen
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·C L MarcusS L Ward
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·P EntzianP Zabel
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·M YounesW Shewchuk
Oct 22, 2003·Sleep & Breathing = Schlaf & Atmung·Kostas ChristouKostantinos I Gourgoulianis
Aug 20, 2004·American Journal of Respiratory and Critical Care Medicine·Andrew WellmanDavid P White
Mar 11, 2005·The American Journal of Cardiology·Raouf S AminStephen R Daniels
Aug 16, 2005·American Journal of Respiratory and Critical Care Medicine·David P White
Jul 15, 2006·American Journal of Respiratory and Critical Care Medicine·Silke RyanWalter T McNicholas
Jan 31, 2007·The Journal of Allergy and Clinical Immunology·Gilles DevouassouxJean-Louis Pépin
Feb 24, 2007·The Journal of Physiology·Andrew WellmanDavid P White
Aug 29, 2012·Pediatrics·Carole L MarcusUNKNOWN American Academy of Pediatrics
Oct 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Richard B BerryUNKNOWN American Academy of Sleep Medicine
Dec 12, 2012·Mediators of Inflammation·Darlan Pase da RosaNorma Possa Marroni
Dec 15, 2012·Cell Biochemistry and Biophysics·Qian HanJudith Choi Wo Mak
Jan 26, 2013·Journal of Applied Physiology·Andrew WellmanDavid P White
May 23, 2013·The New England Journal of Medicine·Carole L MarcusUNKNOWN Childhood Adenotonsillectomy Trial (CHAT)
Jun 1, 2013·American Journal of Respiratory and Critical Care Medicine·Danny J EckertAndrew Wellman
Jul 28, 2013·Respiratory Physiology & Neurobiology·Melissa L BatesMarlowe W Eldridge
Aug 31, 2013·Journal of Applied Physiology·Danny J Eckert, Magdy K Younes
Mar 19, 2014·Sleep Medicine Reviews·Pablo E BrockmannJose A Castro-Rodriguez
Jul 20, 2014·Respiratory Physiology & Neurobiology·Elnaz GederiAndrew Wellman
Jan 15, 2015·JAMA : the Journal of the American Medical Association·Mihaela TeodorescuPaul E Peppard
Nov 22, 2015·Respiratory Physiology & Neurobiology·Plamen BokovChristophe Delclaux
Jul 30, 2016·Journal of Applied Physiology·Toshihiro ImamuraGabriel G Haddad
Nov 4, 2016·Allergy·J Serrano-ParienteUNKNOWN CPASMA Trial Group
Apr 23, 2017·Brain, Behavior, and Immunity·Jordan GainesEdward O Bixler
Oct 27, 2017·Journal of Asthma and Allergy·Yen Nguyen-HoangSy Duong-Quy
Jan 13, 2018·American Journal of Respiratory and Critical Care Medicine·Keren Armoni DomanyRaouf S Amin

❮ Previous
Next ❯

Citations

May 24, 2020·Pediatric Pulmonology·Olufunke Afolabi-Brown, Ignacio E Tapia
Jul 1, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Raouf Amin, Michael Khoo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Keren Armoni DomanyRaouf S Amin
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Ron Mitchell, James Kelly
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
Jing ZhaoBei Li
Archives of Otolaryngology--head & Neck Surgery
Ron MitchellNaomi Yao
© 2022 Meta ULC. All rights reserved