The effect of adipose-derived stem cell-cultured media on oxazolone treated atopic dermatitis-like murine model.

Annals of Dermatology
Hae-Jin LeeEung Ho Choi

Abstract

A stem cell is an undifferentiated cell that has the potential for self-renewal and differentiation. Adipose-derived stem cells (ADSCs) have advantages in accessibility and abundance compared to other kinds of stem cells and produce many growth factors and hormones. We investigated whether ADSC cultured media could be used as a therapy for atopic dermatitis. ADSC cultured media was topically applied twice daily for 5 days to oxazolone-treated atopic dermatitis-like hairless mice. Topical application of ADSC cultured media improved the epidermal permeability barrier and keratinocyte differentiation, and restored the predominant Th2 phenotype when compared to vehicle. ADSC cultured media-treated epidermis also showed an increase in the expression of antimicrobial peptides cathelin-related antimicrobial peptide, mouse beta-defensein 3. Topical ADSC cultured media could be useful in the treatment of atopic dermatitis.

References

Oct 11, 2002·The New England Journal of Medicine·Peck Y OngDonald Y M Leung
Mar 2, 2005·The Journal of Investigative Dermatology·Eung-Ho ChoiKenneth R Feingold
Oct 19, 2007·The Journal of Investigative Dermatology·Karin M AbergPeter M Elias
Feb 17, 2009·Trends in Immunology·Yuping Lai, Richard L Gallo
Apr 7, 2010·Stem Cells and Development·Meindert J CropMartin J Hoogduijn
Jul 21, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G M O'Regan, A D Irvine

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Citations

Jan 28, 2017·Experimental & Molecular Medicine·Gyong Hwa HongYou Sook Cho
Jul 6, 2014·Allergy, Asthma & Immunology Research·Hae-Jin Lee, Seung-Hun Lee
Jan 29, 2019·Experimental Dermatology·Hyun-Sun ParkJi-Ung Park

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Methods Mentioned

BETA
biopsy
electrophoresis
cytokine profile

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