The effect of administering gonadotropin-releasing hormone agonist with recombinant-human growth hormone (GH) on the final height of girls with isolated GH deficiency: results from a controlled study

The Journal of Clinical Endocrinology and Metabolism
G SaggeseL Fiore

Abstract

To assess whether delaying puberty may improve final height in GH-deficient children with a poor height prediction at early puberty, we studied 24 girls with isolated GH deficiency until they reached their final height, in a controlled trial. Patients were taking recombinant human GH (r-hGH) substitutive therapy from 2.1 +/- 0.5 yr (0.1 IU/kg.day sc) before entering the study, without showing any improvement in height prediction (149.6 +/- 2.9 vs.150.3 +/- 2.2 cm) on entering puberty. Fourteen girls agreed to add a GnRH agonist (GnRHa) to r-hGH, whereas the remaining 10 decided against it and served as controls. At the start of the study, girls treated with or without GnRHa had similar auxological characteristics (bone age, 10.9 +/- 0.6 vs. 10.7 +/- 1.3 yr; height SD score for chronological age, -1.87 +/- 0.3 vs. -1.82 +/- 0.2), including pubertal development. The GnRHa (long-acting D-Trp-6-GnRH) was given at 60 microg/kg im every 28 days for 1.9 +/- 0.9 yr, then patients continued the r-hGH at the same dosage (3.1 +/- 0.7 yr). At the end of the study, bone age was 16.2 +/- 0.3 yr in GnRHa-treated girls and 16.6 +/- 0.9 yr in controls. Bone maturation was significantly slower during GnRHa (1.4 +/- 0.2 yr), and height SD score f...Continue Reading

Citations

Jan 5, 2002·Expert Opinion on Investigational Drugs·E A Eugster, O H Pescovitz
Aug 3, 2012·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·S BechtoldH Schmidt
Jun 16, 2015·The Journal of Pediatrics·Erica A Eugster
Apr 1, 2012·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Toshiaki TanakaReiko Horikawa
Jun 9, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Jan M Wit, Wilma Oostdijk
Sep 19, 2017·The Cochrane Database of Systematic Reviews·Chin Fang NgimMeow-Keong Thong
May 29, 2020·The Cochrane Database of Systematic Reviews·Chin Fang NgimMeow-Keong Thong
Mar 24, 2004·Paediatric Drugs·Mark HarrisWayne S Cutfield

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