The effect of adolescence and advanced maternal age on the incidence of complete and partial molar pregnancy

Gynecologic Oncology
Allison Ann GockleyRoss Stuart Berkowitz

Abstract

To compare the age-specific incidence of complete (CM) and partial molar (PM) pregnancy in a large tertiary care center in the United States. Incidence rates of CM and PM per 10,000 live births were calculated using databases from Brigham and Women's Hospital, between 2000 and 2013. Age-specific rates were calculated for women younger than 20 years old (adolescents), 20-39 years old (average age), and 40 years and older (advanced maternal age). Pearson χ(2) test was used to evaluate potential differences among groups. Rate ratios (RR) and 95% confidence intervals (CI) were used to compare risk of molar pregnancy among average age women with that of adolescents and women of advanced age. Holm-Bonferonni adjustment was used to correct for multiple comparisons. Between 2000 and 2013, there were 255 molar pregnancies (140 CM and 115 PM) and 105,942 live births, corresponding to a molar pregnancy rate of 24 per 10,000 live births (95% CI 21-27). Rates of CM and PM were 13 (95% CI 11-16) and 11 (95% CI 9-14) per 10,000 live births respectively. The incidence of CM differed significantly among maternal age groups (p<0.001). Compared to average age women, adolescents were 7.0 times as likely to develop CM (95% CI 3.6-8.9, p<0.001), and...Continue Reading

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Citations

Oct 1, 2020·BJOG : an International Journal of Obstetrics and Gynaecology
Oct 14, 2020·Scientific Reports·Helle LundLone Sunde
Aug 20, 2021·International Journal of Women's Health·Itamar GlickMisgav Rottenstreich
Jun 1, 2021·American Journal of Obstetrics and Gynecology·Benjamin B AlbrightLaura J Havrilesky
Dec 29, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Prashida Guha SarkarPinky Khatri

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