The effect of adrenaline on the contraction of human muscle

The Journal of Physiology
C D Marsden, J C Meadows


1. Infusions of adrenaline in physiological amounts alter human muscle contractions evoked by nerve stimulation.2. Adrenaline shortens the duration of the slow calf muscle twitch, but has no effect on the fast twitch of adductor pollicis.3. Adrenaline decreases unfused tetanic tension and increases the oscillation of tension in 10/sec tetani of calf muscle and adductor pollicis. The usual rise of tension and decrease in oscillation in unfused tetani (;ramp' phenomenon) is abolished.4. Adrenaline has no effect on maximal tetanic tension or maximal rate of rise of tension in a fused tetanus of adductor pollicis.5. The effects of adrenaline on human muscle are due to stimulation of beta-adrenotropic receptors, for they are abolished by the beta-adrenotropic antagonist DL-propranolol (but not by D-propranolol), and are mimicked by isoprenaline but not by noradrenaline.6. The effect of adrenaline on adductor pollicis is abolished by local beta-blockade of one arm with intra-arterial DL-propranolol, indicating that the responsible beta-receptors lie peripherally.7. The changes in muscle contraction observed cannot be explained by altered muscle temperature, for this falls during adrenaline infusion; nor are they due to an action on n...Continue Reading


May 1, 1981·Indian Journal of Pediatrics·V Kalra, R K Marwaha
Jan 1, 1980·Medical & Biological Engineering & Computing·J C StevensN B Jones
Feb 22, 1997·Lancet·P Brown
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·D O ThomasC T Davies
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·K Sahlin, J Y Seger
Jan 1, 1982·European Journal of Applied Physiology and Occupational Physiology·C T DaviesM J White
Apr 24, 2010·European Journal of Applied Physiology·A LegrosR Z Stodilka
Oct 1, 1976·General Pharmacology·P V Sulakhe, P J St Louis
Jun 19, 2013·The Journal of Physiology·Silvestro Roatta, Dario Farina
Jan 1, 1979·Annals of the New York Academy of Sciences·G A RodanR I Sha'afi
Sep 25, 2015·The Journal of Physiology·Simeon P Cairns, Fabio Borrani
Nov 20, 2009·Experimental Physiology·M Lakie
Oct 1, 1984·American Heart Journal·N L FosterT N Chase
Jul 1, 1988·British Journal of Pharmacology·I Wessler, S Anschütz
Jan 1, 1990·Clinical and Experimental Pharmacology & Physiology·I WesslerA Künster
Aug 1, 1995·Journal of Sports Sciences·M LakieR Wilby
Jan 1, 1978·British Journal of Pharmacology·R S Gupta, V V Kelkar
Jul 1, 1978·Clinical and Experimental Pharmacology & Physiology·W C Bowman, M W Nott
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·P KrackA L Benabid
Dec 1, 1989·Muscle & Nerve·J H Williams, W S Barnes
Jan 1, 1983·Microsurgery·R C Harwell, R L Ferguson
Sep 1, 2018·Journal of Neural Engineering·Alie J BuckmireAndrew J Fuglevand
Oct 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·D JeffersonC D Marsden
May 1, 1975·Journal of Neurology, Neurosurgery, and Psychiatry·M Takamori
Apr 1, 1971·Journal of Neurology, Neurosurgery, and Psychiatry·R E Sica, A J McComas
May 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·A J McComasA R Upton
Mar 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·R R Young, K E Hagbarth
Jan 1, 1985·European Journal of Applied Physiology and Occupational Physiology·C T Davies, D W Starkie
Aug 1, 2013·Medicine and Science in Sports and Exercise·Giacomo Crivelli, Nicola A Maffiuletti
Jan 10, 2013·Medicine and Science in Sports and Exercise·Giacomo CrivelliNicola A Maffiuletti
Apr 1, 1976·The Journal of Pharmacy and Pharmacology·W C Bowman, C Raper
Jan 1, 1986·Acta Medica Scandinavica. Supplementum·C T DaviesM J White
Jul 27, 2000·Medicine and Science in Sports and Exercise·M A van BaakF Hartgens
Mar 11, 2017·Journal of the South African Veterinary Association·Stephanie S De LangeLeith C R Meyer
Apr 2, 2011·Journal of Applied Physiology·Silvestro Roatta, Dario Farina
Nov 23, 2020·European Journal of Applied Physiology·Ian C SmithWalter Herzog

Related Concepts

Nerve Impulses

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.