PMID: 16520300Mar 8, 2006Paper

The effect of Aegle marmelos fruit extract in streptozotocin diabetes: a histopathological study

Journal of Herbal Pharmacotherapy
N Kamalakkannan, P Stanely Mainzen Prince

Abstract

Aegle marmelos Correa. (Bael) fruit exhibit antidiabetic, antihyperlipidaemic and antioxidant properties. This study was designed to elucidate the protective effect of an aqueous extract of Aegle marmelos fruits on the histopathology of the pancreas in streptozotocin-induced diabetic rats. Oral administration of Aegle marmelos fruit extract at doses of 125 and 250 mg/kg twice daily to diabetic rats for a period of 30 days resulted in a significant increase in body weight, weight of the pancreas and insulin levels associated with a significant decrease in fasting blood glucose levels. The fruit extract treated groups showed improved functional state of the pancreatic ss-cells and partially reversed the damage caused by streptozotocin to the pancreatic islets. The findings of our study indicate that Aegle marmelos fruit extract exhibits protective effects on the pancreas. The effects observed in the fruit extract treated animals were better those in animals treated with glibenclamide (300 microg/kg).

References

Dec 1, 1989·Journal of Ethnopharmacology·M D IvorraA Villar
Apr 1, 1987·Journal of Pharmaceutical Sciences·O SiddiquiY W Chien
Jun 1, 2000·Journal of Molecular Endocrinology·S Bonner-Weir
Jul 16, 2003·Journal of Ethnopharmacology·N Kamalakkannan, P Stanely Mainzen Prince
Aug 26, 2003·Journal of Medicinal Food·N KamalakkananP Stanely Mainzen Prince

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Citations

Dec 27, 2012·BMC Complementary and Alternative Medicine·Watcho PierreKamanyi Albert
Nov 26, 2009·BMC Complementary and Alternative Medicine·S BrijeshTannaz Birdi
Jun 2, 2012·Pharmacognosy Reviews·Pathirage Kamal Perera, Yunman Li
Nov 10, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shaik Sameena FatimaChippada Appa Rao
Dec 11, 2007·Journal of Ethnopharmacology·T S Fröde, Y S Medeiros
Dec 23, 2017·Archives of Physiology and Biochemistry·Walid Hamdy El-Tantawy, Abeer Temraz

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