The effect of age and temperature on mdx muscle fatigue

Muscle & Nerve
M A WineingerR T Abresch

Abstract

We have studied the in vitro contractile and fatigue characteristics of extensor digitorum longus (EDL) muscles from 8- and 62-week-old dystrophin-deficient (mdx) and control mice at 20 degrees C and 35 degrees C. There were no differences in fatigability at 20 degrees C, but at 35 degrees C the dystrophin-deficient muscles demonstrated increased fatigability compared to controls, with the older mice exhibiting the greatest fatigue. These results suggest a temperature-related mechanism of myofibrillar fatigue in dystrophin-deficient EDL muscles.

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Citations

Sep 7, 2014·The Journal of Physiology·James G Tidball, Michelle Wehling-Henricks
Nov 11, 2006·Journal of Applied Physiology·James G Tidball, Michelle Wehling-Henricks
Nov 1, 2002·American Journal of Physical Medicine & Rehabilitation·Mark A WineingerTed Abresch
Oct 28, 2009·Molecular and Cellular Biochemistry·Felicity J WatersMiranda D Grounds

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