PMID: 3746689May 1, 1986Paper

The effect of age on energy metabolism and resistance to ischaemic conduction failure in rat peripheral nerve

The Journal of Physiology
P A LowK K Ward

Abstract

Caudal nerve conduction velocity and amplitude of nerve action potential increased progressively with age to 8 months after which time no further increases were demonstrated. Rat peripheral nerve was progressively more resistant to ischaemic-anoxic conduction failure with increasing age. This resistance to ischaemic conduction failure was paralleled by a progressive age-related decline in endoneurial O2 consumption. Endoneurial adenosine triphosphate and creatine phosphate values were also progressively reduced with age. 15 min of anoxia resulted in progressively smaller reductions in these nucleotide phosphates with increasing age to 8 months after which time little further change occurred. Nerve lactate response to anoxia was higher in young rats (1 and 2 months) than in older animals (8 and 21 months). High energy phosphate expenditure progressively declined with age to 8 months, then stabilized. These findings indicate that the major mechanism of resistance to ischaemic conduction failure is a progressive decline in energy requirements.

Citations

Mar 1, 1991·Acta Physiologica Scandinavica·P Lindström, T Brismar
Mar 15, 1990·Mechanisms of Ageing and Development·J KoistinahoS I Rapoport
Oct 23, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark SteckerMatthew Stevenson
Oct 23, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark SteckerMatthew Stevenson
Apr 20, 2010·Brain Research·Mark M SteckerMatthew Stevenson
Apr 25, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·S K JankelowitzDavid Burke
Sep 17, 2004·Computers in Biology and Medicine·G C Sharma, Madhu Jain
Nov 18, 2004·Journal of the Neurological Sciences·Yanping WangPhillip A Low
Sep 1, 1987·Microvascular Research·T D Lagerlund, P A Low
Jan 1, 1993·Computers in Biology and Medicine·T D Lagerlund, P A Low
Jan 1, 1988·Experimental Aging Research·D G Hazzard, J Soban
Mar 30, 2011·Acta Cirúrgica Brasileira·Celina Cordeiro de CarvalhoSílvia Regina Arruda de Moraes
Jan 1, 1995·Annals of Neurology·M KiharaP A Low
Jun 17, 2020·Expert Review of Neurotherapeutics·Roberta BonomoDebra J Skene
Oct 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D ChooS I Rosenberg
Aug 30, 2018·Journal of Medical Ultrasonics·Satoshi TabakoTakanori Ikeda
Aug 1, 1994·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D W Zochodne, L T Ho
Oct 1, 1987·The American Journal of Physiology·M Takeuchi, P A Low
Jun 1, 1994·Progress in Neurobiology·K C Wadhwani, S I Rapoport

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