The Effect of Age on Mortality in Patients With COVID-19: A Meta-Analysis With 611,583 Subjects.

Journal of the American Medical Directors Association
Clara BonanadAlberto Cordero

Abstract

Initial data on COVID-19 infection has pointed out a special vulnerability of older adults. We performed a meta-analysis with available national reports on May 7, 2020 from China, Italy, Spain, United Kingdom, and New York State. Analyses were performed by a random effects model, and sensitivity analyses were performed for the identification of potential sources of heterogeneity. COVID-19-positive patients reported in literature and national reports. All-cause mortality by age. A total of 611,1583 subjects were analyzed and 141,745 (23.2%) were aged ≥80 years. The percentage of octogenarians was different in the 5 registries, the lowest being in China (3.2%) and the highest in the United Kingdom and New York State. The overall mortality rate was 12.10% and it varied widely between countries, the lowest being in China (3.1%) and the highest in the United Kingdom (20.8%) and New York State (20.99%). Mortality was <1.1% in patients aged <50 years and it increased exponentially after that age in the 5 national registries. As expected, the highest mortality rate was observed in patients aged ≥80 years. All age groups had significantly higher mortality compared with the immediately younger age group. The largest increase in mortality...Continue Reading

References

Jul 26, 2011·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins
Mar 9, 2020·Journal of Infection in Developing Countries·Rossella PorchedduSalvatore Rubino
Mar 17, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jing YangYongning Zhou
Mar 18, 2020·JAMA : the Journal of the American Medical Association·Edward Livingston, Karen Bucher
Apr 16, 2020·Revista española de cardiología·Clara BonanadUNKNOWN Los autores firmantes pertenecen a las siguientes entidades científicas
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Safiya RichardsonTheodoros P Zanos

❮ Previous
Next ❯

Citations

Jan 2, 2021·Journal of the American Medical Directors Association·Geoffrey OdilleAlain Putot
Jan 9, 2021·Journal of the American Medical Directors Association·Rafael BielzaJorge Gómez Cerezo
Jan 24, 2021·Journal of the American Medical Directors Association·Ruth PiersNele Van Den Noortgate
Nov 14, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Elliot McClenaghanUNKNOWN Global Registry Harmonization Group
Jan 9, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Noémie GirardAlain Putot
Jan 21, 2021·QJM : Monthly Journal of the Association of Physicians·L BaileyR Briggs
Dec 23, 2020·Archives of Gerontology and Geriatrics·Raymond PranataSiti Setiati
Dec 8, 2020·Archives of Gerontology and Geriatrics·Timotius Ivan HariyantoAndree Kurniawan
Dec 18, 2020·International Journal of Environmental Research and Public Health·Eduardo Gutiérrez-AbejónFrancisco Herrera-Gómez
Nov 21, 2020·BMC Public Health·N David YanezMiriam M Treggiari
Feb 5, 2021·The Lancet Infectious Diseases·Silvia StringhiniUNKNOWN Specchio-COVID19 Study Group
Feb 9, 2021·Tobacco Induced Diseases·Adinat UmnuaypornlertSurasak Saokaew
Feb 18, 2021·Zeitschrift für Gerontologie und Geriatrie·R WirthJ M Bauer
Mar 4, 2021·International Journal of Health Services : Planning, Administration, Evaluation·Mehak Nanda, Rajesh Sharma
Mar 5, 2021·Risk Management and Healthcare Policy·Bocong YuanGuojun Zeng
Mar 10, 2021·BMJ Health & Care Informatics·Fatma MansabDaniel Goyal
Aug 5, 2020·Revista española de geriatría y gerontología·José Ramón Caeiro-ReyFrancisco José Tarazona-Santabalbina
Mar 26, 2021·Journal of the Air & Waste Management Association·Kamal Jyoti MajiDheeraj Alshetty
Mar 27, 2021·Journal of Gerontological Social Work·Wai ChanShiyu Lu
Mar 27, 2021·Journal of the American Geriatrics Society·Sergio Salmerón RíosPedro Abizanda
Mar 31, 2021·Transfusion·Monika LindemannAdalbert Krawczyk
Jun 24, 2020·Journal of Hepatology·Mohammed A Medhat, Mohamed El Kassas
Apr 29, 2021·Sleep & Breathing = Schlaf & Atmung·Frances ChungUNKNOWN International COVID Sleep Study (ICOSS) group
May 7, 2021·Clinical Interventions in Aging·Melissa K AndrewJanet E McElhaney
Dec 29, 2020·ACS Biomaterials Science & Engineering·Bader M JaraiCatherine A Fromen
May 14, 2021·BMJ : British Medical Journal·Santiago Romero-BrufauThomas C Kingsley
May 22, 2021·Neurology. Neuroimmunology and Neuroinflammation·Mahdi BarzegarAmir-Hadi Maghzi
May 22, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Jack PhuMargaret Zhong

❮ Previous
Next ❯

Software Mentioned

Stata
Google Scholar

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.