PMID: 8614079May 1, 1996Paper

The effect of age on peripheral motor nerve function after crush injury in the rat

The Journal of Trauma
B M BelinS E Mackinnon

Abstract

To determine the ontogeny of functional recovery after peripheral nerve crush injury. Comparative study in rats of varying ages. Sixty-second crush injury was performed on the left posterior tibial nerve. Control animals underwent either nerve transection or sham procedure. Nerve function was evaluated 2, 4, and 8 weeks following injury by walking track analysis. Print length ratio (PLR), (ratio of normal right-sided print length to experimental left-sided print length), was used to evaluate functional recovery. Two weeks after crush injury, adult rats experienced significantly greater functional impairment than both 4-day-old and 3-week-old animals (p < 0.05). Four weeks after injury, the difference in function between 4-day-old and adult rats and between 3-week-old and adult rats became insignificant. Complete recovery had been achieved by 8 weeks in all groups. These results demonstrate faster functional recovery after nerve injury in immature rats than in adults.

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Citations

May 16, 2000·Journal of Biomechanics·C S HowardC A Peimer
May 10, 2003·Clinics in Plastic Surgery·Jeffrey R Marcus, Howard M Clarke
Jun 16, 1999·The Laryngoscope·P G ReddyR H Mathog
Sep 30, 2008·Somatosensory & Motor Research·Roman PavićMarija Heffer-Lauc
Feb 14, 2006·The Journal of Hand Surgery·Julie E Adams, Scott P Steinmann
Feb 13, 2001·Experimental Neurology·T B LeT M Brushart
Nov 13, 2008·Journal of Neuroscience Methods·Aline de Souza PagnussatCarlos Alexandre Netto
Sep 25, 2004·Muscle & Nerve·Tejashree S MalushteMark Gonzalez
Jul 25, 2006·Annals of Plastic Surgery·Jason R HessSusan E Mackinnon

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