PMID: 8950646Nov 1, 1996Paper

The effect of age on residual strain in the rat aorta

Journal of Biomechanical Engineering
A Badreck-AmoudiS E Greenwald

Abstract

Residual stress is observed in many parts of the cardiovascular system and is thought to reduce transmural stress gradients due to intravascular pressure. Its development is closely associated with normal growth and pathological remodeling, although there appear to be few previous reports of the relationship between aging and residual stress. We have estimated residual strain (an indicator of the magnitude of residual stress) at ten sites along the aorta of rats aged 2.5 to 56 weeks by measuring the degree to which rings of vessel spring open when cut (opening angle). At all ages the opening angle decreased along the aorta, reaching a minimum near the renal arteries and increasing toward the aorto-iliac bifurcation, a result that confirms previous studies. During growth, although the unloaded circumference of the aorta increased steadily, the wall thickness and medial surface area fell to a minimum at the age of 6 weeks before continuing a steady increase. Similarly, the opening angle decreased between the ages of 2.5 and 6 weeks, thereafter increasing with age. In the abdominal aorta, a strong correlation between opening angle and wall thickness relative to midwall radius (h/R) was seen; whereas in the thoracic segment, in whi...Continue Reading

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Citations

Jan 6, 2009·Biomechanics and Modeling in Mechanobiology·L CardamoneJ D Humphrey
Feb 8, 2007·Annals of Biomedical Engineering·Gerhard A HolzapfelRay W Ogden
Apr 16, 2003·Journal of Biomechanics·A Rachev, S E Greenwald
Nov 24, 2001·Medical Engineering & Physics·Y DouH Gregersen
Jan 4, 1998·Journal of Biomechanical Engineering·S E GreenwaldJ J Meister
Jul 21, 1999·Journal of Biomechanical Engineering·J H OmensA D McCulloch
Aug 13, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Hans GregersenJingbo Zhao
Jul 12, 2001·Annual Review of Biomedical Engineering·L A Taber
Jul 20, 2007·The Cochrane Database of Systematic Reviews·K Mahomed
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jingbo ZhaoHans Gregersen

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