PMID: 3756405Aug 1, 1986Paper

The effect of age on the autonomic innervation of the urinary bladder

British Journal of Urology
S A GilpinR S Kirby

Abstract

Quantitative methods have been used to assess the amount of autonomic nerve in bladder biopsy samples from a group of "control" patients ranging in age from 20 to 79 years. Each patient included in the study was urodynamically normal and showed no subjective evidence of bladder trabeculation at cystoscopy. Using light microscopy, a significant linear reduction in the amount of acetylcholinesterase-positive nerve was observed with increasing age. Counts of axon profiles and measurement of smooth muscle cell cross-sectional areas in the electron microscope revealed a similar reduction in the amount of nerve per mm2 of detrusor muscle tissue. These findings thus confirm that a real reduction in the number of nerve axons occurs with age and the light microscope results are not due merely to a reduction in the amount of nerve-associated acetylcholinesterase. The present study provides baseline data for future comparisons of the density of autonomic innervation in bladders which are functionally impaired.

References

Aug 1, 1986·The Journal of Urology·J A GoslingC J Gilpin
Oct 1, 1985·British Journal of Urology·S A GilpinR J Barnard

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Citations

May 25, 1999·Neurourology and Urodynamics·S MadersbacherM Marberger
Jan 1, 1993·Neurourology and Urodynamics·M SaitoR M Levin
Sep 1, 1992·Journal of Neurocytology·G GabellaB Uvelius
Apr 1, 1995·Diseases of the Colon and Rectum·C T SpeakmanG Burnstock
Aug 28, 2009·Current Urology Reports·Anne M Suskind, Phillip P Smith
May 16, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·L BombierS R Shaw
Apr 29, 1998·British Journal of Pharmacology·C PinnaG Burnstock
Jan 1, 1992·British Journal of Urology·J A Cumming, G D Chisholm
Oct 1, 1992·British Journal of Urology·C R ChappleG Burnstock
Feb 1, 1994·British Journal of Urology·C R Chapple, D Smith
Jul 9, 2014·Nature Reviews. Urology·Marcus J DrakeDominika A Bijos
Oct 22, 2014·Nature Reviews. Urology·Nadir I Osman, Christopher R Chapple
Jun 9, 2006·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·A Wagg
Jan 10, 2008·Taiwanese Journal of Obstetrics & Gynecology·Gin-Den Chen
Jan 25, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Adrian Wagg
Jun 11, 2011·Neurourology and Urodynamics·G A van KoeveringeM Oelke
Sep 18, 2009·Neurourology and Urodynamics·Phillip P Smith
Dec 1, 1987·British Journal of Urology·S C HarrisonP T Doyle
Nov 1, 1987·British Journal of Urology·H F ParkhouseR T Turner-Warwick
Apr 1, 1996·The Journal of Urology·G E LeachP E Zimmern
Aug 1, 1996·The Urologic Clinics of North America·F HaabG E Leach
Sep 3, 2004·Clinics in Geriatric Medicine·Rafi Kevorkian
May 3, 2005·The Urologic Clinics of North America·Thomas M KesslerUrs E Studer
Feb 22, 2017·Current Opinion in Urology·Reem Aldamanhori, Christopher R Chapple
Jun 7, 2003·Menopause : the Journal of the North American Menopause Society·Yi-Ching ChenLong-Yau Lin
Dec 28, 2017·Investigative and Clinical Urology·Naoki Aizawa, Yasuhiko Igawa
Dec 28, 2017·Investigative and Clinical Urology·Toby C Chai, Tambudzai Kudze

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