PMID: 8947606Nov 1, 1996Paper

The effect of age on the transendothelial migration of human T lymphocytes

Scandinavian Journal of Immunology
P StohlawetzP Pietschmann

Abstract

Since the migration of immunologically active cells into perivascular tissue is an important step in acute and chronic inflammation, the authors studied the possible influence of age on the transendothelial migration of T cells in an in vitro model. After incubation on collagen gels coated with human endothelial cells, three populations of T cells of elderly and young subjects were harvested: non-adherent (NAD), bound (BND) and migrated (MIG) cells. The percentages of the BND and MIG fractions were similar in the young and elderly groups. Phenotypic analysis showed that in the starting population of the elderly subjects T-cell subpopulations that have an increased capacity of transendothelial migration (e.g., CD4+ memory cells, CD8+/CD57+ cells) were enriched: nevertheless ageing was not associated with an increase in the transendothelial migration of T cells.

Citations

Dec 30, 1999·Veterinary Immunology and Immunopathology·F A Zuckermann
May 22, 2002·Biochimica Et Biophysica Acta·Vaea Richard de SoultraitMichel Fournier
Apr 18, 2000·Experimental Gerontology·P PietschmannM Peterlik
Apr 1, 1997·Trends in Microbiology·S CudmoreM Way
Oct 11, 2011·Cellular & Molecular Immunology·Stefania CaneUsha Ponnappan
Nov 7, 2001·Clinical and Experimental Dermatology·M Grewe
Sep 22, 1998·Scandinavian Journal of Immunology·P StohlawetzP Pietschmann
Jan 25, 2002·Annals of the New York Academy of Sciences·J M IsnerT Asahara
May 23, 1998·Annual Review of Immunology·R W DuttonS L Swain
May 4, 1999·The Journal of Clinical Investigation·J M Isner, T Asahara
Aug 17, 2014·Experimental Gerontology·Jasmina DjikićGordana Leposavić
Jun 9, 2006·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·S KudlacekP Pietschmann
Jan 13, 1999·Circulation·A RivardJ M Isner
Aug 1, 1998·Japanese Journal of Cancer Research : Gann·S TsuzukiM Miyasaka

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