The effect of ageing on function and quality of life in ileal pouch patients: a single cohort experience of 409 patients with chronic ulcerative colitis

Annals of Surgery
Dieter HahnloserR R Dozois

Abstract

To evaluate in what manner ageing affects functional outcome and quality of life (QoL) in patients with chronic ulcerative colitis (CUC) after ileal pouch-anal anastomosis (IPAA). Short-term function and QoL after IPAA is good. However, patients are usually young, and little is known about the influence of time and ageing on long-term outcomes after IPAA. Using a standardized questionnaire, functional outcome, QoL, and complications were assessed prospectively in a cohort of 409 patients followed annually for 15 years after IPAA. Follow-up was complete in the single cohort of 409 patients and functional and QoL outcomes summarized at 5, 10, and 15 years. Daytime stool frequency changed little (mean 6), while nighttime frequency increased from 1 stool to 2 stools. Incontinence for gas and stool increased from 1% to 10% during the day and from 2% to 24% at night over 15 years. The cumulative probability of pouchitis increased from 28% at 5 years to 38% at 10 years and to 47% at 15 years. Bowel obstruction and stricture were other principal long-term complications. At 15 years, 91% of patients had kept the same job. Work was not affected by the surgery in 83%, while social activities, sports, traveling, and sexual life all improve...Continue Reading

Associated Clinical Trials

References

Feb 1, 1992·Current Problems in Surgery·K A KellyR R Dozois
Oct 1, 1987·Annals of Surgery·J H PembertonD M Ilstrup
Dec 23, 1993·The New England Journal of Medicine·A H SultanC I Bartram
Apr 15, 1993·Annals of Internal Medicine·G H GuyattD L Patrick
Jan 1, 1997·International Journal of Colorectal Disease·A M RyhammerF H Sørensen
Jan 1, 1997·International Journal of Colorectal Disease·H T TanM R Keighley
Apr 24, 1999·The British Journal of Surgery·K O OlsenT Oresland
Nov 23, 2000·Diseases of the Colon and Rectum·C S YuD Larson
Jun 8, 2001·Diseases of the Colon and Rectum·J M RegimbeauP Valleur
Jan 25, 2002·Annals of Surgery·Anthony R MacLeanRobin S McLeod
Oct 24, 2002·Diseases of the Colon and Rectum·Anna LepistöHeikki J Järvinen
Mar 27, 2003·American Journal of Surgery·Robert M WeinrybJ Petter Gustavsson
Jun 5, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E CarmonM Rabau
Aug 2, 2003·Annals of Surgery·Hagit TulchinskyJohn Nicholls
Oct 24, 2003·The American Journal of Gastroenterology·Jean-Frederic ColombelWilliam J Sandborn

❮ Previous
Next ❯

Citations

Jul 9, 2020·Irish Journal of Medical Science·Kevin McKevittJohn P Burke
Jul 13, 2018·Current Treatment Options in Gastroenterology·James Q ZhouShannon Chang
Dec 17, 2008·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Amy K MooreWendy Thal
Jun 1, 2020·International Journal of Colorectal Disease·Jara E JonkerPaul M A Broens
Apr 10, 2009·The British Journal of Surgery·M BlockT Oresland
Jun 17, 2006·The British Journal of Surgery·S W PolleW A Bemelman
Jan 17, 2007·The British Journal of Surgery·D HahnloserR R Dozois
Jun 16, 2007·The British Journal of Surgery·B B McGuireP R O'Connell
Jun 14, 2008·The British Journal of Surgery·J W OgilvieR D Madoff
Apr 15, 2021·Diseases of the Colon and Rectum·Stefan D HolubarUNKNOWN Prepared on behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Jul 8, 2014·Journal of Visceral Surgery·A TriguiR Mzali
Jul 13, 2021·Therapeutic Advances in Gastroenterology·Wendy Rabbenou, Shannon Chang
Dec 13, 2005·The New England Journal of Medicine·Paul RutgeertsJean Frédéric Colombel
Nov 1, 2005·Diseases of the Colon and Rectum·Jeffrey L CohenUNKNOWN Standards Practice Task Force American Society of Colon and Rectal Surgeons
Aug 22, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J LindbergJ Rutegård
Aug 31, 2006·Journal of Clinical Gastroenterology·Gary R LichtensteinRobert H Diamond
Sep 6, 2006·Gastroenterology Clinics of North America·Arthur F StucchiJames M Becker
May 8, 2007·Journal of the American College of Surgeons·Chelliah R SelvasekarJohn H Pemberton
May 19, 2007·Techniques in Coloproctology·D J HochmanT Tantitemit
Sep 1, 2007·Diseases of the Colon and Rectum·Ina BerndtssonLars Börjesson
Nov 2, 2007·Inflammatory Bowel Diseases·Marc FerranteAndre D'Hoore
Jan 30, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M G A NorwoodD Hemingway
Jul 15, 2009·Gastroenterology·William J SandbornJean Frédéric Colombel
Nov 13, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R P KiranV W Fazio
Nov 3, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R A PintoS D Wexner
Dec 18, 2007·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·M VellaW S Hendry
Dec 17, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T AnderssonA Nesbakken
Mar 30, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·H H WasmuthH E Myrvold
Aug 28, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A P SaklaniJ Beynon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.