PMID: 377005Jun 1, 1979Paper

The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly

Metabolism: Clinical and Experimental
M B Davidson

Abstract

There seems little doubt that the disposal of a glucose load is progressively impaired during aging. The mechanism(s) for this alteration remains unclear. Five possibilities have been raised: (1) poor diet, (2) physical inactivity, (3) decreased lean body mass in which to store the carbohydrate load, (4) decreased insulin secretion, and (5) insulin antagonism. Although poor diet and physical inactivity may contribute to some of the abnormal glucose tolerance tests of the older population, these two factors do not provide a full explanation. Diminished lean body mass may play some role but there is almost certainly an additional effect due to aging. A few papers have suggested that glucose-induced insulin secretion may be impaired as the population ages, but the bulk of studies in this area conclude that normal or increased amounts of insulin are released by the pancreatic beta-cell during aging. If abnormalities of insulin secretion exist, either in degree or timing, they are subtle and would not seem sufficient to account for the great number of older subjects who manifest impaired glucose tolerance. The evidence for insulin antagonism seems the strongest but the data are certainly not conclusive. In actuality, the aging effec...Continue Reading

References

May 1, 1977·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M B Davidson, L E Gerschenson
Jun 1, 1975·Endocrinology·J M Olefsky, G M Reaven
Oct 1, 1975·The Journal of Clinical Investigation·A H SoliJ Roth
Jul 1, 1978·Diabetologia·G Gonen, A H Rubenstein
Dec 1, 1978·Metabolism: Clinical and Experimental·M B Davidson
Jan 1, 1976·The American Journal of Medicine·G M ReavenJ M Olefsky
Jan 1, 1977·Metabolism: Clinical and Experimental·R J Dudl, J W Ensinck
Jul 1, 1977·Journal of the American Geriatrics Society·E Bracho-Romero, G M Reaven
Aug 1, 1977·Journal of the American Geriatrics Society·G KimmerlingG M Reaven
May 1, 1977·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C IpJ Tepperman
Jun 1, 1976·The Journal of Clinical Investigation·M P Czech
Jan 1, 1976·Journal of the American Geriatrics Society·J M Feldman, J W Plonk
Jun 12, 1975·European Journal of Clinical Investigation·J F Rehfeld, F Stadil
Sep 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J P Palmer, J W Ensinck
Jan 1, 1975·Advances in Experimental Medicine and Biology·R Andres, J D Tobin
Sep 1, 1975·Acta diabetologica latina·A Gommers, H Genne
Feb 5, 1966·Lancet·T A WelbornR Fraser
Apr 15, 1967·Lancet·C ChlouverakisH Keen
Jun 15, 1968·Lancet·F I MartinA E Stocks
Jun 28, 1969·Lancet·B I JoffeW P Jackson
Mar 1, 1969·Archives of Internal Medicine·N B RudermanE Shafrir
Jul 1, 1969·Journal of Gerontology·M FriedmanD E Sharland
Dec 5, 1974·European Journal of Clinical Investigation·F M HansenJ Gliemann
Sep 1, 1974·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·O O Ogundipe, A Bray
Jan 1, 1974·Acta diabetologica latina·M K SinhaG K Rastogi
Dec 11, 1974·Biochemical and Biophysical Research Communications·J N Livingston, D H Lockwood
Jul 1, 1972·The Journal of Clinical Investigation·R L Lerner, D Porte
Mar 1, 1974·Journal of Gerontology·B K Lewis, B C Wexler
Nov 1, 1974·Metabolism: Clinical and Experimental·P Björntorp
Feb 1, 1972·Diabetes·R L LipmanJ J Schnure
Nov 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·D R Romsos, G A Leveille
May 1, 1973·American Journal of Obstetrics and Gynecology·N Phillips, T Duffy
Mar 1, 1973·Journal of the American Geriatrics Society·S NolanT S Danowski

❮ Previous
Next ❯

Citations

Jan 1, 1991·European Journal of Clinical Pharmacology·A E PontiroliG Pozza
Jan 1, 1986·European Journal of Applied Physiology and Occupational Physiology·A H GoldfarbL VanderVelden
May 28, 1980·Molecular and Cellular Biochemistry·G M Reaven, E P Reaven
Aug 1, 1994·Digestive Diseases and Sciences·W A KleinS Cohen
Apr 1, 1980·Acta diabetologica latina·E PisuG Pagano
Sep 1, 1990·Aging : Clinical and Experimental Research·F BeccaroG Crepaldi
Apr 16, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·K NakashimaY Andoh
Jan 1, 1981·Metabolism: Clinical and Experimental·G PaganoG Lenti
Jul 1, 1995·Metabolism: Clinical and Experimental·W T CefaluR Anderson
Mar 1, 1996·Physiology & Behavior·L L Bernardis, P J Davis
Nov 1, 1984·Mechanisms of Ageing and Development·R L KhandelwalN Narayanan
Apr 1, 1988·Mechanisms of Ageing and Development·L de ClercqC Remacle
Dec 1, 1988·Mechanisms of Ageing and Development·N KalantR Kaplan
Aug 1, 1989·Mechanisms of Ageing and Development·B W CraigR Brown
Dec 2, 1991·Mechanisms of Ageing and Development·J L IvyJ O Holloszy
Jan 31, 1995·Mechanisms of Ageing and Development·H BakalaJ Schaeverbeke
Jul 1, 1994·Mechanisms of Ageing and Development·D A PodolinR S Mazzeo
Oct 1, 1989·Pharmacology, Biochemistry, and Behavior·D M Connelly, P V Taberner
Mar 1, 1991·Archives of Gerontology and Geriatrics·A Ruiz-Torres
Jan 1, 1992·Archives of Gerontology and Geriatrics·A Mysliwski, Z Kmiec
Jan 1, 1996·Archives of Gerontology and Geriatrics·F S FeruglioV Motta
Jan 1, 1981·Experimental Gerontology·B C Wexler
Jan 1, 1983·Experimental Gerontology·Z Kmieć, A Myśliwski
Jan 1, 1987·Experimental Gerontology·A Fraselle-JacobsC Remacle
Jan 1, 1990·Experimental Gerontology·M R Odio, A Brodish
Jul 19, 2003·Metabolism: Clinical and Experimental·Bente BryhniJorunn H Eikrem
Jul 11, 2001·Neuroscience and Biobehavioral Reviews·C R Park
Jul 26, 2008·Archives of Gerontology and Geriatrics·D RossoG Carnazzo
Nov 5, 2002·Diabetes Research and Clinical Practice·Satoshi KatoHidetoshi Yamashita
Mar 1, 1997·Diabetes Research and Clinical Practice·L HiltunenS Keinänen-Kiukaanniemi
Aug 14, 2003·Experimental Gerontology·Norika Tamaya-MoriAkihisa Iguchi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved