PMID: 374898Feb 1, 1979Paper

The effect of aging on sister chromatid exchange

Mechanisms of Ageing and Development
E L SchneiderM L Nieder

Abstract

The advent of the bromodeoxyuridine(BrdU)-differential staining techniques has greatly facilitated the detection of sister chromatid exchanges (SCE). These SCE have been demonstrated to be an accurate reflection of DNA damage both in vitro in cultured cells and in vivo in mouse and rate bone marrow and spleen cells. In this review, we examine the effect of cellular aging on both baseline and mutagen-induced SCE levels. In all systems examined, aging did not appear to significantly affect the baseline levels of SCE. However, in human fibroblast cultures we have found a significant decrease in the levels of mutagen-induced SCE as a function of both in vitro passage level (in vitro aging) and the age of the cell culture donor (in vivo aging). In addition we have found a similar decrease in mutagen-induced SCE levels in both mouse and rat bone marrow cells and mouse spleen cells where examinations were performed entirely in vivo. Diminished mutagen-induced SCE levels were obtained with a wide variety of agents including mitomycin-C, cyclophosphamide, adriamycin, ethyl methanesulfonate and N-acetyl-2-acetoxyamino-fluorene. These decreased SCE levels were accompanied by increased frequencies of chromosomal aberrations in the older ce...Continue Reading

References

May 1, 1979·Mutation Research·Y Nakanishi, E L Schneider
Jul 1, 1977·Journal of the National Cancer Institute·N C PopescuJ A DiPaolo
Apr 1, 1977·Science·W W NicholsS A Dwight
Jul 1, 1976·Experimental Cell Research·E L SchneiderR R Tice
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S A LattP S Gerald
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S A Latt
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D KramE L Schneider

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Citations

Jan 1, 1985·Mutation Research·M Fenech, A A Morley
Feb 1, 1979·Mechanisms of Ageing and Development·E L SchneiderG Bynum
Jan 1, 1985·Molecular Aspects of Medicine·A K Roy, B Chatterjee
Jul 1, 1985·Epilepsia·B SchaumannJ Cervenka
Mar 25, 2008·DNA Repair·Dominika M Wiktor-BrownBevin P Engelward
Jan 1, 1987·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·X M CheJ Borneff
Jun 1, 1983·Journal of the American Geriatrics Society·E L Schneider
Jan 7, 1982·Journal of Theoretical Biology·C B HarleyS Goldstein

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