The effect of aging on the utilization of chemotherapy for metastatic breast cancer: a population-based study

Cancer Investigation
J H FettingR Smith

Abstract

Older women (i.e., > or = 65 years of age) receive less adjuvant chemotherapy than younger women, in part because chemotherapy has been less effective in postmenopausal than premenopausal women in clinical trials. Metastatic breast cancer, however, does not respond differently to chemotherapy by age. Therefore, to evaluate further the effect of age on chemotherapy utilization, we conducted a population-based study of the treatment of metastatic breast cancer. Patients (n = 132) were identified by cross-tabulating death certificates from 1984 to 1991 with breast cancer cases in the Washington County Cancer Registry. Treatment information was obtained from the Tumor Registry of the Washington Country Hospital and Hospital medical records. Forty patients (74%) < 65 years old received chemotherapy compared to 11 (42%) 65-74 and 6 (12%) > or = 75 (p < 0.0001). Adjusting for other medical conditions and whether or not the patient saw a medical oncologist, there was still a significant effect of age in patients > or = 75 (p < 0.001) and a trend (p = 0.17) for patients 65-74. The different patterns of chemotherapy utilization were not associated with survival differences. Radiation therapy was also utilized significantly less frequentl...Continue Reading

References

Apr 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D I JodrellE Wiltshaw
Jul 1, 1992·JAMA : the Journal of the American Medical Association·K ChristmanV Stanley
Mar 1, 1989·Neurobiology of Aging·W G DarlingS H Brown
Feb 23, 1989·The New England Journal of Medicine·E G MansourG Falkson
Dec 14, 1973·Science·J Wennberg, Gittelsohn
May 1, 1970·The Proceedings of the Nutrition Society·S W Cox
Nov 1, 1994·Journal of Clinical Epidemiology·M CharlsonJ Gold
May 5, 1994·The New England Journal of Medicine·W C WoodC R Ferree
Oct 6, 1993·Journal of the National Cancer Institute·P A Newcomb, P P Carbone

❮ Previous
Next ❯

Citations

Feb 19, 2000·Hematology/oncology Clinics of North America·B Zachariah, L Balducci
Oct 16, 2013·International Journal of Cancer. Journal International Du Cancer·Elena BonoraFabienne Lesueur

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
C I RodriguesA B Karim
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
A C ThompsonP J Bradley
Archives of Gerontology and Geriatrics
Claudia Beghe, Lodovico Balducci
© 2021 Meta ULC. All rights reserved