The effect of airway pressure and oscillation amplitude on ventilation in pre-term infants

The European Respiratory Journal
Martijn MiedemaAnton H van Kaam

Abstract

We determined the effect of lung recruitment and oscillation amplitude on regional oscillation volume and functional residual capacity (FRC) in high-frequency oscillatory ventilation (HFOV) used in pre-term infants with respiratory distress syndrome (RDS). Changes in lung volume, oscillation volume and carbon dioxide levels were recorded in 10 infants during a stepwise recruitment procedure, and an increase in pressure amplitude of 5 cmH(2)O was measured using electrical impedance tomography and transcutaneous monitoring. The pressures at maximal respiratory system compliance, maximal oscillation volume and minimal carbon dioxide levels were determined. Impedance data were analysed for the chest cross-section and predefined regions of interest. Despite the fixed pressure amplitude, the oscillation volume changed during the incremental pressure steps following a parabolic pattern, with an inverse relationship to the carbon dioxide pressures. The pressures corresponding with maximal compliance, maximal oscillation volume and minimal carbon dioxide were similar and highly correlated. Regional analysis showed similar findings. The increase in pressure amplitude resulted in increased oscillation volumes and decreased carbon dioxide ...Continue Reading

Citations

Oct 22, 2015·Expert Review of Respiratory Medicine·Bo GongZhanqi Zhao
Mar 16, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Francesca CiuffiniDavid G Tingay
Apr 18, 2014·Current Opinion in Critical Care·Inéz FrerichsNorbert Weiler
May 27, 2015·Physiological Measurement·Christian J RothWolfgang A Wall
Sep 20, 2019·Acta Paediatrica·Arrabella KingAtul Malhotra
Dec 10, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yonni FriedlanderGiles Santyr
Aug 31, 2018·Scientific Reports·Christian J RothAndreas W Flemmer
Nov 15, 2017·Pediatric Pulmonology·Barbara VogtInéz Frerichs
Nov 29, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Jessica ThomsonDavid G Tingay
Oct 24, 2020·American Journal of Respiratory and Critical Care Medicine·Vincent D GaertnerChristoph M Rüegger
Jun 22, 2021·Critical Care Explorations·David G TingayPeter A Dargaville

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