The effect of alcohol stress on nicotinamide adenine dinucleotide (NAD+) levels in Drosophila

Biochemical Genetics
K C McElfresh, J F McDonald

Abstract

Previous studies carried out in mammalian systems indicated that an organism's NAD+/NADH balance is carefully regulated but can be destabilized by dietary stresses. Since Drosophila alcohol dehydrogenase (ADH) uses NAD+ to remove a hydrogen from ethanol in the first step of alcohol catabolism, it is possible that under alcohol stress conditions the in vivo NAD+ levels in Drosophila may decrease. In this study genetically homozygous flies were stressed with maximally sublethal concentrations of ethanol (10%) for periods of up to 24 hr. The results indicate that NAD+ levels do in fact drop by at least 20% in response to ethanol stress. Evidence is presented that suggests that this decrease is the direct result of ADH-mediated catabolism.

References

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Citations

Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S M Anderson, J F McDonald
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J VouidibioJ R David
Jun 16, 2015·Oxidative Medicine and Cellular Longevity·Jade GuestRoss Grant
Jan 1, 1997·Hereditas·K Bokor, K Pecsenye
Jan 9, 2021·Oxidative Medicine and Cellular Longevity·Borut PoljsakIrina Milisav

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