The effect of alkaline phosphatase and intrahepatic metastases in large hepatocellular carcinoma

World Journal of Surgical Oncology
Jong Man KimCheol-Keun Park

Abstract

Hepatectomy is the standard treatment for HCC. However, large HCC poses a difficult challenge because of the technical complexity of surgical resection and the fear of postoperative hepatic decompensation. We analyzed the outcome and prognostic factors in patients with large hepatocellular carcinoma (HCC ≥10 cm) after surgery. We retrospectively investigated the medical records of 91 patients who had undergone hepatectomy between January 2006 and June 2010. A survival analysis was performed utilizing the Kaplan-Meier method and prognostic factors were evaluated using Cox regression analysis. Of the 91 patients evaluated, most tumors were associated with hepatitis B virus (HBV). The median tumor size was 12.3 cm (range, 10 to 21 cm), with microvascular invasion present in most patients. The postoperative mortality rate was 2.2%. The median disease-free survival and overall survival were six months and 41 months. The one-year, two-year, and three-year disease-free survival rates were 33.5%, 29.3%, and 18.8%, respectively. The one-year, two-year, and three-year overall survival rates were 73.9%, 63.7%, and 54.8%, respectively. Of the 89 surviving patients, 69 patients (77.5%) developed HCC recurrence during the mean follow-up peri...Continue Reading

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Citations

Jun 27, 2014·Indian Journal of Clinical Biochemistry : IJCB·Ujjawal SharmaRajendra Prasad
Jan 13, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xing LvYong Chen
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Sep 10, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Ariyo MovahediFauziah Othman
Jan 24, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jong Man KimJoon Hyeok Lee
Mar 10, 2018·Annals of Surgical Treatment and Research·Jong Man KimJae-Won Joh
Sep 5, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jong Man KimKyung-Suk Suh
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Apr 10, 2018·Annals of Surgical Treatment and Research·Jong Man KimSeung Woon Paik
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Sep 15, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sung-Mi JungJae-Won Joh

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Methods Mentioned

BETA
surgical resection
dissection

Software Mentioned

SPSS

Related Concepts

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