Aug 1, 1976

The effect of allyl compounds on hepatic microsomal mixed function oxidation and porphyrogenesis

Chemico-biological Interactions
C Ioannides, D V Parke


The activities of 5-aminolaevulinate (5-ALA) synthetase and of various microsomat drug-metabolising enzymes have been determined in the livers of rats pretreated with different drugs and chemicals containing the allyl group. Safrole, isosafrole and secobarbital gave rise to slight increases in 5-ALA synthetase, whereas alclophenac and triallyl cyanurate almost doubled the enzyme activity and the known porphyrogenic agents, allylisopropylacetamide (AIA) and allobarbital caused increases of 1.5- and 2.5-fold, respectively. Allobarbital induced the microsomal drug-metabolising enzymes while secobarbital had only a weak effect and alclophenac and triallyl cyanurate had no effect at all. From these results it is suggested that induction of the synthesis of cytochrome P-450 is not rate dependent on the synthesis haem and induction of porphyrin biosynthesis.

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Mentioned in this Paper

Structure-Activity Relationship
5-Aminolevulinate synthase
Microsomes, Liver
Mixed Function Oxygenases
Allyl Compounds

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