Oct 1, 1975

The effect of alpha-adrenolytics on the levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in rat's brain

Polish Journal of Pharmacology and Pharmacy
I Zebrowska-Lupina, Z Kleinrok

Abstract

Alpha-Adrenolytics (ABA)-phenoxybenzamine, phentolamine and aceperone-increase 5-hydroxyindoleacetic (5-HIAA) acid content in rat's brain. At the same time, these compounds either increase or do not affect 5-hydroxytryptamine (5-HT) level. Moreover, they potentiate L-dopa and reserpine-induced increase in 5-HIAA level and antagonized clonidine-induced decrease in 5-HIAA content. The experiments with probenecid indicate that the observed increase in 5-HIAA does not result from the deficient elimination of the metabolite from brain. The increase in 5-HT turnover in brain, due to ABA, is suggested.

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Mentioned in this Paper

Z-Max
Phenoxybenzamine Hydrochloride
Serotonin
Brain
Adrenergic alpha-Antagonists
Butyrophenones
V-Serp
Brain Chemistry
Reserpine
Biochemical Turnover

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