The effect of altered sodium balance upon renal vascular reactivity to angiotensin II and norepinephrine in the dog. Mechanism of variation in angiotensin responses

The Journal of Clinical Investigation
J A Oliver, P J Cannon

Abstract

The mechanism whereby the vasoconstrictor response to angiotensin II (AII) is influenced by sodium balance or disease is unclear. To explore this question, the renal vascular responses (RVR) to intrarenal injections of subpressor doses of AII and norepinephrine were studied in dogs with an electromagnetic flowmeter. Acute and chronic sodium depletion increased plasma renin activity (PRA) and blunted the RVR to AII, while acute sodium repletion and chronic sodium excess plus desoxycorticosterone acetate decreased PRA and enhanced the RVR to AII. The magnitude of the RVR to AII was inversely related to PRA. The RVR to norepinephrine was unaffected by sodium balance and was not related to PRA. Inhibition of the conversion of angiotensin I to AII by SQ 20,881 during sodium depletion lowered mean arterial blood pressure (MABP), increased renal blood flow (RBF), and enhanced the RVR to AII but not to norepinephrine. Administration of bradykinin to chronically sodium-depleted dogs also lowered the MABP and increased RBF but had no effect on the RVR to AII. SQ 20,881 had no effect on MABP, RBF, or the RVR to AII in the dogs with chronic sodium excess and desoxycorticosterone acetate. Administration of indomethacin to chronically sodium...Continue Reading

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Citations

Jun 15, 1984·European Journal of Pharmacology·D D Smyth, H Y Fung
Nov 1, 1979·Journal of Steroid Biochemistry·Y UedaM Hatano
Oct 1, 1980·The Journal of Clinical Investigation·J A OliverP J Cannon
Oct 1, 1984·The Journal of Clinical Investigation·J A Oliver, R R Sciacca
Nov 1, 1981·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L I RankinF C Luft
Oct 1, 1987·Kidney International·P F FaubertJ G Porush
Jul 1, 1980·Hypertension·L G Meggs, N K Hollenberg
May 1, 1981·Circulation Research·P A JohnstonN G Levinsky
Jul 1, 2020·The Journal of Clinical Investigation·Wakako KawarazakiToshiro Fujita
Feb 26, 2021·Nature Reviews. Nephrology·Wakako Kawarazaki, Toshiro Fujita
Apr 4, 2021·International Journal of Molecular Sciences·Wakako Kawarazaki, Toshiro Fujita
Jul 9, 1979·Life Sciences·A Nasjletti, K U Malik

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