PMID: 7514018Feb 1, 1994Paper

The effect of aluminum chloride on some steps of heme biosynthesis in rats after oral exposure

Biological Trace Element Research
J ChmielnickaE Lewandowska-Zyndul

Abstract

Certain disturbances in heme biosynthesis induced by aluminum chloride were examined. The experiment was performed on female rats that received AlCl3 orally at the dose 100 mg Al/kg daily for 21 d. The effects of aluminum on the activity of delta-aminolevulinic acid synthetase (ALA-S), dehydratase (ALA-D), and heme oxygenase (O.H.) were observed on 3, 7, 14, and 21 d in liver and kidneys of rats. Also the activity of ALA-D in blood and the concentration of delta-aminolevulinic acid (ALA-U) in urine were observed. Orally administered aluminum caused increase in the activity of ALA-D in the liver and blood, and parallel decrease of ALA-U in urine (r = -0.85) of rats. Aluminum chloride also induced an increase of ALA-S and O.H. in the liver but not in the kidneys. The changes of the enzymes activity participating in heme biosynthesis after administration of aluminum may be correlated with anemia and iron metabolism in rats.

References

Oct 15, 1979·Archives of Biochemistry and Biophysics·S ShibaharaG Kikuchi
Nov 1, 1979·Archives of Environmental Health·M AbdullaB Haeger-Aronsen
Apr 15, 1977·International Archives of Occupational and Environmental Health·S Tola, C H Nordman
Jun 16, 1977·The New England Journal of Medicine·W D KaehnyA C Alfrey
Dec 1, 1975·Epilepsia·J J CereghinoB G White
Jan 22, 1976·The New England Journal of Medicine·A C AlfreyW D Kaehny
Dec 1, 1992·Ecotoxicology and Environmental Safety·J ChmielnickaU Grabowska
Aug 1, 1992·Biological Trace Element Research·G Zareba, J Chmielnicka
Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J B CannataJ H Brock
Sep 1, 1988·Proceedings of the Society for Experimental Biology and Medicine·P AllainY Mauras
Apr 1, 1986·Ecotoxicology and Environmental Safety·G ZarebaG Kustra
Nov 1, 1985·Environmental Health Perspectives·M R Wills, J Savory
Jan 1, 1985·Toxicology and Applied Pharmacology·H FujitaM Ikeda
Jan 1, 1985·Nephron·R J McGonigle, V Parsons
Apr 1, 1985·Acta Pharmacologica Et Toxicologica·P SlaninaP Mattsson
Nov 1, 1974·Archives of Environmental Health·K Tomokuni
Feb 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Lione
Jul 25, 1983·Life Sciences·G A Trapp
May 1, 1981·British Journal of Industrial Medicine·J ChmielnickaJ A Szymańska
Jan 1, 1993·Biological Trace Element Research·J ChmielnickaA Korycka
Nov 1, 1991·Biological Trace Element Research·J Chmielnicka, M Nasiadek

❮ Previous
Next ❯

Citations

Oct 18, 2000·Toxicology Letters·V L Pimentel VieiraP C do Nascimento
Jun 5, 2002·Toxicology Letters·M FarinaJ B T Rocha
Jun 18, 2003·Critical Reviews in Toxicology·Edward J Calabrese, Linda A Baldwin
Feb 24, 2005·Toxicology·M FarinaJ B T Rocha
Jul 19, 2002·Environmental Research·Prasunpriya Nayak
Feb 13, 2001·Ecotoxicology and Environmental Safety·M NasiadekJ Subdys
Apr 4, 2007·International Journal of Occupational Medicine and Environmental Health·Tadeusz HałatekJacek Gruchała
Dec 4, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sumonto MitraShashi Khandelwal
Oct 13, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yanzhu ZhuZhigang Zhang
Mar 7, 2000·Ecotoxicology and Environmental Safety·M Nasiadek, J Chmielnicka
Sep 9, 2004·Journal of Occupational and Environmental Medicine·Y-H LiaoC-C Chang
Aug 12, 2006·Journal of Occupational and Environmental Medicine·Yen-Hsiung LiaoTar-Ching Aw
Dec 31, 2005·Journal of Neurosurgery. Spine·Brian D StemperFrank A Pintar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Maria R C SchetingerS R Rodrigues
Lancet
G M BerlyneG M Danovitch
© 2021 Meta ULC. All rights reserved