The effect of aminoglycoside-induced adaptive resistance on the antibacterial activity of other antibiotics against Pseudomonas aeruginosa in vitro

The Journal of Antimicrobial Chemotherapy
M L BarclayB A Peddie

Abstract

The effect of gentamicin-induced adaptive resistance on the antibacterial activity of six non-aminoglycoside antibiotics was studied. Adaptive resistance was induced in Pseudomonas aeruginosa in a dynamic in-vitro model of infection. The bactericidal effect of ceftazidime, imipenem, aztreonam, ciprofloxacin, and piperacillin was not altered in the presence of adaptive resistance but the effect of rifampicin was increased.

Citations

Feb 4, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Lucía FernándezRobert E W Hancock
Oct 20, 2006·Journal of Clinical Pharmacology·Mette Maja B TeigenDavid W Johnson
Feb 22, 2001·American Journal of Surgery·W P English, M D Williams
Apr 29, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B MarthaP Chavanet
Jun 25, 2018·Clinical Pharmacokinetics·Jürgen B BulittaCornelia B Landersdorfer

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