The effect of aminopterin-induced folic acid deficiency on spermatogenesis

Fertility and Sterility
U MathurB B Mathur

Abstract

Folic acid deficiency was produced by injecting aminopterin into adult male albino rats, resulting in inhibition of spermatogenesis. Bone marrow smears were studied to serve as an index of folic acid deficiency; however, changes in spermatogenesis were noticed earlier than the bone marrow changes. Meiotic division was affected more than mitotic division. The nuclei of spermatogenic cells showed degenerative changes. Chromosomal abnormalities, chiefly sticky chromosomes, were noticed in squashed preparations of seminiferous tubules.

Citations

Nov 30, 2007·American Journal of Physical Anthropology·Esteban J Parra
Jan 1, 1984·Nutrition and Health·A Wynn
Oct 6, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·M Laura DántolaAndrés H Thomas
Mar 9, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·Peter M EliasJohn Jack W Williams
Dec 24, 2005·American Journal of Physical Anthropology·Heather L NortonMark D Shriver
Jun 11, 2009·Pigment Cell & Melanoma Research·Peter M EliasJohn Jack W Williams
Dec 17, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Bruna Oliveira MissaggiaMaria Cátira Bortolini

Related Concepts

Aminopterin, Disodium Salt
Metazoa
Marrow
Folic Acid Deficiency
Spermiogenesis
Testis
Rats, Laboratory

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