PMID: 108731Mar 22, 1979

The effect of amitriptyline and mianserine (Org. GB94) on food motivated behaviour of rats trained in a runway: possible correlation with biogenic amine concentration in the limbic system

J EganB E Leonard


Rats on a 23 h food deprivation schedule were trained to run down a straight runway for a food reward. Neither amitriptyline nor mianserine had an effect on the running time for the food reward during the period of continuous reinforcement. However both antidepressants delayed the extinction of this response. It seems unlikely that this effect on extinction was due to an altered motivation for the food reward as amitriptyline significantly decreased the food intake of the experimental animals while mianserine increased the food intake throughout the period of the experiment. The observation that both these antidepressants reduce the speed of extinction of rewarded behaviour may be explicable in terms of observed changes in the concentration of biogenic amines in the limbic system.


Aug 1, 1975·Japanese Journal of Pharmacology·C KameiM Shimizu
Mar 1, 1977·Pharmakopsychiatrie, Neuro-Psychopharmakologie·B E Leonard
Feb 1, 1968·The Journal of Pharmacy and Pharmacology·A CarlssonU Ungerstedt
Oct 1, 1974·Psychological Bulletin·D P Cain
Jan 1, 1973·Psychopharmacologia·C B Saper, D C Sweeney
May 1, 1973·Pharmacology, Biochemistry, and Behavior·S Ahlenius
Jan 1, 1968·Psychological Review·A Routtenberg
Sep 1, 1969·Journal of Comparative and Physiological Psychology·J A Gray
May 1, 1965·Biochemical Pharmacology·S H SnyderM Zweig
May 1, 1965·Biochemical Pharmacology·S UdenfriendT Nagatsu


Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·P L Thurlby, R Samanin
Jun 1, 1993·Pharmacology, Biochemistry, and Behavior·P PetitG Ribes
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·Sandra E File, J C Tucker
Jan 1, 1990·Pharmacology & Therapeutics·H van Riezen, B E Leonard
Jan 1, 1990·Pharmacology & Therapeutics·C F Flaherty
Jan 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·A Fundarò
Jun 1, 1983·Pharmacology, Biochemistry, and Behavior·P L ThurlbyR Samanin
Sep 5, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J M Mancilla-DíazS E Cruz-Morales
Mar 17, 2004·Eating and Weight Disorders : EWD·J M Mancilla-DíazV E López-Alonso
May 10, 2018·Neurochemical Research·Darya A MeshalkinaAllan V Kalueff

Related Concepts

Biogenic Amines
Brain Chemistry
Extinction, Psychological
Food Deprivation (Experimental)
Memory Training
Limbic System

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.