The effect of an ethanol extract derived from fenugreek (Trigonella foenum-graecum) on bile acid absorption and cholesterol levels in rats

The British Journal of Nutrition
A Stark, Z Madar

Abstract

The hypocholesterolaemic properties of an ethanol extract from defatted fenugreek (Trigonella foenum-graecum) seeds were investigated. Purification of the crude extract by dialysis produced an isolated component with haemolytic properties. The dialysate was also found to contain saponins demonstrated by thin-layer chromatography. Experiments in vitro employing the everted-sac technique showed that the ethanol extract had the ability to inhibit taurocholate and deoxycholate absorption in a dose-dependent manner. In two separate feeding experiments, hypercholesterolaemic rats were fed on 30 or 50 g ethanol extract/kg for a 4-week period. Reductions in plasma cholesterol levels ranged from 18 to 26% and a tendency for lower concentrations of liver cholesterol was observed. These results indicate that the ethanol extract from fenugreek seeds contained hypocholesterolaemic components which appear to be saponins that interact with bile salts in the digestive tract.

References

Dec 1, 1977·The American Journal of Clinical Nutrition·M R MalinowP R Cheeke
Jun 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·G RibesM M Loubatieres-Mariani
Jan 1, 1987·Critical Reviews in Food Science and Nutrition·K R PriceG R Fenwick
Jan 1, 1988·European Journal of Clinical Pharmacology·G PaolissoF D'Onofrio
May 1, 1986·The British Journal of Nutrition·G S Sidhu, D G Oakenfull
Apr 1, 1971·Journal of the Science of Food and Agriculture·B GestetnerA Bondi
Oct 1, 1966·Biochemical Pharmacology·R SegalD V Zaitschek
Jan 1, 1984·Atherosclerosis·G ValetteG Ribes
Jan 1, 1984·Atherosclerosis·M R Malinow
Jun 1, 1984·The American Journal of Clinical Nutrition·J A StoryG V Vahouny
Mar 1, 1960·Clinica Chimica Acta; International Journal of Clinical Chemistry·R L SEARCY, L M BERGQUIST

❮ Previous
Next ❯

Citations

Apr 1, 2003·Current Therapeutic Research, Clinical and Experimental·Derek E Woodgate, Julie A Conquer
Mar 29, 2001·Journal of Ethnopharmacology·P Sharma, J D Sharma
Apr 12, 2001·Journal of Ethnopharmacology·A AhmadianiM Kamalinejad
May 22, 2002·Journal of Ethnopharmacology·J K GroverV Vats
Dec 25, 2002·The British Journal of Nutrition·Zecharia Madar, Aliza H Stark
Dec 21, 2002·The British Journal of Nutrition·George FrancisKlaus Becker
Nov 14, 2014·International Journal of Molecular Sciences·Zakia BenayadNour Eddine Es-Safi
Sep 30, 2010·Phytotherapy Research : PTR·Urmila AswarPrasad Arvind Thakurdesai
Apr 14, 2016·Journal of Dietary Supplements·Megh Shyam Sharma, Prema Ram Choudhary
Oct 10, 2013·Pharmaceutical Biology·Umesh C S Yadav, Najma Z Baquer
Apr 2, 2015·Journal of Food Science and Technology·Suresh D SakharePichan Prabhasankar
Mar 10, 2015·Critical Reviews in Food Science and Nutrition·S BalasubramanianS N Saxena
Oct 22, 2016·Analytical and Bioanalytical Chemistry·Mohamed A FaragAndreas G Heiss
Apr 30, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Mahmoud BahmaniMahmoud Rafieian-Kopaei
Sep 6, 2001·Phytotherapy Research : PTR·T Zia Nazrul-Hasnain
Feb 16, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J Raju, R P Bird
Dec 1, 2005·Phytotherapy Research : PTR·Priyanjali DixitThomas P A Devasagayam
Dec 6, 2005·Molecular and Cellular Biochemistry·Mohamed Z GadNibal D El-Tanbouly
Apr 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Sara OufquirAbderrahman Chait
Mar 6, 1999·Journal of the American College of Nutrition·M A ZuletJ A Martínez
Oct 28, 2019·Journal of Food Biochemistry·Subramaniyam NithyananthanChinnasamy Thirunavukkarasu
Jan 29, 2020·Scientific Reports·Annadora J Bruce-KellerJacqueline M Stephens
Jan 30, 2010·Journal of Agricultural and Food Chemistry·Olfa Belguith-HadricheFatma Makni-Ayedi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.