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The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit

Genetics

Dec 3, 2016

Casper-Emil T PedersenAnders Albrechtsen

Abstract

The genetic consequences of population bottlenecks on patterns of deleterious genetic variation in human populations are of tremendous interest. Based on exome sequencing of 18 Greenlandic Inuit we show that the Inuit have undergone a severe ∼20,000-year-long bottleneck. This has led to...read more

Mentioned in this Paper

Patterns
Whole Exome Sequencing
Human Migration
Sequencing
Genetic Equilibrium
Bnk protein, Drosophila
Genetic Load
Simulation
Alleles
Inuit Population
40
66
1
Paper Details
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The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit

Genetics

Dec 3, 2016

Casper-Emil T PedersenAnders Albrechtsen

PMID: 27903613

DOI: 10.1534/genetics.116.193821

Abstract

The genetic consequences of population bottlenecks on patterns of deleterious genetic variation in human populations are of tremendous interest. Based on exome sequencing of 18 Greenlandic Inuit we show that the Inuit have undergone a severe ∼20,000-year-long bottleneck. This has led to...read more

Mentioned in this Paper

Patterns
Whole Exome Sequencing
Human Migration
Sequencing
Genetic Equilibrium
Bnk protein, Drosophila
Genetic Load
Simulation
Alleles
Inuit Population
40
66
1

Feeds With Similar Papers

Comparative Sequencing

Inter/Intra-Species: Comparative Sequencing describes the sequencing techniques that compare between and within species genomes. Discover the latest research on comparative sequencing of inter/intra-species here.

Related Papers

Nature Genetics

The deleterious mutation load is insensitive to recent population history

Nature GeneticsFebruary 11, 2014
Yuval B SimonsGuy Sella
PLoS Genetics

Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck

PLoS GeneticsSeptember 1, 2015
Daniel J BalickShamil R Sunyaev
Paper Details
References
  • References
  • Citations8
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations8
1

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