PMID: 11310206Apr 20, 2001Paper

The effect of an osteolytic tumor on the three-dimensional trabecular bone morphology in an animal model

Skeletal Radiology
Andreas A Kurth, Ralph Müller

Abstract

To investigate the application of micro-computed tomography (microCT) for the assessment of density differences and deterioration of three-dimensional architecture of trabecular bone in an experimental rat model for tumor-induced osteolytic defects. Walker carcinosarcoma 256 malignant breast cancer cells (W256) were surgically implanted into the medullary canal of the left femur of 15 4-month-old rats. Twenty-eight days after surgery all animals were killed and both femora from each rat were harvested. A total of 30 specimens (left and right femur) were scanned in a desktop microCT imaging system (microCT 20, Scanco Medical) to assess densitometric and architectural parameters. For each specimen a total of 200 micro-tomographic slices with a resolution of 30 microns in the distal metaphysis was taken. Bone mineral content (BMC) was analyzed for both cortical and trabecular bone (ctBMC), and for trabecular bone only (tBMC). Architectural indices (BV/TV, Tb.N, Tb.Th, Tb.Sp) according to standard definitions used in histomorphometry were calculated for trabecular bone. The quantitative analysis of density parameters revealed significantly (P < 0.001) lower values for ctBMC and tBMC in the tumor-bearing group (T) of 26% and 31%, re...Continue Reading

Citations

May 4, 2006·Clinical & Experimental Metastasis·Stéphane BlouinDaniel Chappard
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Clinton RubinYi-Xian Qin
Aug 15, 2003·Dento Maxillo Facial Radiology·F KobayashiT Maeda
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Perry J PickhardtJamey P Weichert
Mar 3, 2011·Journal of Biomedical Optics·Jun HuDa Xing
May 10, 2005·Expert Review of Anticancer Therapy·Robert KrempienJürgen Debus
Apr 25, 2007·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·G KuhnF J Rühli
Oct 13, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Matthew P ThorpeDonald K Layman
May 7, 2014·Neurological Research·Cari M Whyne
Jul 15, 2006·International Journal of Cancer. Journal International Du Cancer·Shoichiro OhtaKarel Pacak
Jul 21, 2006·The British Journal of Oral & Maxillofacial Surgery·Candan EfeogluAylin Sipahi
Oct 9, 2004·Physics in Medicine and Biology·In Kon ChunSoo Yeol Lee
Oct 9, 2015·Yonsei Medical Journal·Yoon Sok ChungTaeyong Lee

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