PMID: 5912211Jun 1, 1966

The effect of androgenic hormones on creatinine secretion in the rat

The Journal of Physiology
A M Harvey, R L Malvin

Abstract

1. The stop flow procedure was used to compare the urinary creatinine: inulin ratios in male and female rats; to confirm previous evidence for secretion of creatinine by the renal tubule in the male rat, and to assess the effect of androgenic hormones on this property of the renal tubule in the female rat.2. The creatinine:inulin ratios in free flow and all stop flow samples in the female rat were close to unity, confirming the absence of secretion of creatinine.3. In the male rat the ratios in the free flow samples exceeded 1.2. In samples proximal to the sodium minimum the ratio rose to a peak of 1.56, and then declined to the free flow level.4. Female rats pre-treated with androgenic hormones exhibited a male type pattern. A single intramuscular dose of testosterone, or daily injections of progesterone for 1 month, had a similar effect. The free flow ratios rose to 1.2 and on stop flow a proximal secretory peak was seen.5. Two conclusions may be drawn-the creatinine clearance is a valid measure of glomerular filtration rate in the female rat, but not in the male; and the secretion of creatinine is a function of the proximal tubular cells which can be influenced by androgenic hormones in the rat.

Citations

Feb 13, 2013·Biological Trace Element Research·Mitzi Paola Santoyo-SanchezOlivier Barbier
Aug 26, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J L ReyesE Meléndez
Dec 25, 2009·Kidney International·Christoph EisnerJurgen Schnermann
Oct 28, 2004·Journal of Ethnopharmacology·Ma Estela Meléndez CamargoGuadalupe Miranda
Mar 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Steef J SinkelerGerjan Navis
Nov 8, 2018·American Journal of Physiology. Renal Physiology·Cesar A RomeroOscar A Carretero
Apr 7, 1998·Endocrinology·J L ReyesF Jaramillo-Juárez
Apr 1, 1975·Postgraduate Medical Journal·P Bye
Aug 1, 1990·European Journal of Clinical Investigation·U GafterJ Levi
Sep 10, 2002·American Journal of Physiology. Renal Physiology·G FrindtL G Palmer
Jan 3, 2001·American Journal of Physiology. Renal Physiology·G FrindtL G Palmer

Related Concepts

Creatine
Glomerular Filtration Rate
Intramuscular Injection
Inulin
Kidney Function Tests
Renal Tubule Structure
Natriuresis
Progesterone, (9 beta,10 alpha)-Isomer
Secretory Rate
Phenotypic Sex

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.