The effect of angiotensin-converting enzyme inhibitors of left atrial pressure in dogs with mitral valve regurgitation

Journal of Veterinary Internal Medicine
T IshikawaY Yamane

Abstract

Despite many epidemiological reports concerning the efficacy of angiotensin-converting enzyme (ACE) inhibitors in dogs with mitral regurgitation (MR), the hemodynamic effects of ACE inhibitor administration have not been fully evaluated. To document left atrial pressure (LAP) in dogs with MR administered ACE inhibitors, in order to obtain interesting information about daily LAP changes with administration of ACE inhibitors. Five healthy Beagle dogs weighing 9.8 to 14.2 kg (2 males and 3 females; aged 2 years). Experimental, crossover, and interventional study. Chordae tendineae rupture was induced, and a radiotelemetry transmitter catheter was inserted into the left atrium. LAP was recorded for 72 consecutive hours during which each of 3 ACE inhibitors--nalapril (0.5 mg/kg/d), temocapril (0.1 mg/kg/d), and alacepril (3.0 mg/kg/d)--were administered in a crossover study. Averaged diurnal LAP was significantly, but slightly reduced by alacepril (P = .03, 19.03 +/- 3.01-18.24 +/- 3.07 mmHg). The nightly drops in LAP caused by alacepril and enalapril were significantly higher than the daily drops (P = .03, -0.98 +/- 0.19 to -0.07 +/- 0.25 mmHg, and P = .03, -0.54 +/- 0.21-0.02 +/- 0.17 mmHg, respectively), despite the fact that the...Continue Reading

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Jun 6, 2009·Journal of Veterinary Internal Medicine·T IshikawaY Yamane

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Citations

Feb 15, 2011·Journal of Veterinary Internal Medicine·S SuzukiR Tanaka
Nov 19, 2011·Journal of Veterinary Internal Medicine·S SuzukiR Tanaka
Feb 25, 2014·Research in Veterinary Science·Chayanon ChompoosanWinai Chansaisakorn
Jul 2, 2016·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·A SakataniN Takemura
Mar 2, 2016·Journal of Feline Medicine and Surgery·Keisuke SugimotoKensuke Orito
Jun 26, 2018·The Journal of Veterinary Medical Science·Yasutomo HoriTakahiro Mimura
Jun 23, 2021·Journal of the American Heart Association·Jordan E MorningstarRussell A Norris

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