The effect of angiotensin II on myosin heavy chain expression in cultured myocardial cells

In Vitro Cellular & Developmental Biology. Animal
N ShalitinGania Kessler-Icekson

Abstract

Angiotensin II (AII), the principal mediator of the renin-angiotensin system, is an important regulator of vascular and cardiac homeostasis. AII has also been shown to be a regulator of cardiac hypertrophy and of the corresponding changes in amount and composition of certain tissue proteins. We examined the trophic effects of AII on cultured myocytes derived from neonatal rat ventricles and followed, by Northern blot analysis and polyacrylamide gel electrophoresis, the expression of alpha- and beta-myosin heavy chain iso-mRNAs and isoproteins. Our findings show that a single administration of AII is sufficient to induce a trophic response in cultured beating myocytes and to enhance the expression of beta-myosin heavy chain iso-mRNA and isoprotein, having no effect on alpha-myosin heavy chain. Induction of alpha-myosin heavy chain expression by thyroid hormone before AII was administered showed that AII could not potentiate a shift from alpha- to beta-myosin heavy chain predominance. We suggest that the potency of AII to regulate the expression of myosin heavy chain isogenes is restricted to the beta isoform and is overridden by thyroid hormone.

References

Jan 1, 1992·Annual Review of Physiology·K M BakerD E Dostal
May 1, 1991·Journal of Applied Physiology·C D IanuzzoB Li
Feb 1, 1991·Trends in Pharmacological Sciences·P B TimmermansW F Herblin
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·H HuangP Corvol
Jul 1, 1988·Journal of Molecular and Cellular Cardiology·G Kessler-Icekson
Mar 1, 1980·Analytical Biochemistry·C Labarca, K Paigen
Aug 1, 1981·Circulation Research·J J MercadierK Schwartz
Nov 1, 1984·Experimental Cell Research·G Kessler-IceksonL Wasserman
Dec 1, 1981·Journal of Molecular and Cellular Cardiology·K SchwartzB Swynghedauw
Aug 1, 1995·Circulation Research·T YamazakiK Tobe
Jan 1, 1993·Annual Review of Physiology·I Komuro, Y Yazaki
Jan 1, 1993·Annual Review of Physiology·K R ChienS M Evans
Jun 1, 1993·Circulation Research·W SchorbK M Baker

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Citations

May 29, 2009·The Protein Journal·Yang LiuAihua Lin
Aug 19, 2008·Biological Trace Element Research·Yang LiuBuhai Li
Jan 29, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M ScheinowitzM Eldar
Jan 12, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G Kessler-IceksonA Rephaeli
Mar 30, 2001·The Journal of Thoracic and Cardiovascular Surgery·G SakaguchiW J Louis
Nov 26, 2016·Journal of Cellular Biochemistry·Vitaly KliminskiGania Kessler-Icekson
Jul 21, 1999·Journal of Cardiovascular Pharmacology·H SalmanG Kessler-Icekson
May 29, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ofra GoharEfrat Kessler

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