The effect of anti-B-cell therapy on the development of atherosclerosis in patients with rheumatoid arthritis

Current Pharmaceutical Design
Diana S NovikovaEugeny L Nasonov

Abstract

Accelerated development of atherosclerosis (AT) in rheumatoid arthritis (RA) stems from common immune-inflammatory mechanisms underlying the diseases. While the key role of activation of the T-cell immune system component is considered to be proved, the role of B-lymphocytes has been investigated insufficiently. Earlier experimental models demonstrated the "atheroprotective" role of B-cells. At the same time, AT development is associated with activation of the B-cell immune system component and manifested by hyperproduction of antibodies to oxidized low density lipoproteins (oxLDL), heat shock proteins, etc. Wide applications of anti-B-cell therapy stimulate active research on effects of B-lymphocytes and their depletion on AT development in RA patients that have a high risk of cardiovascular events (CVE). Experimental models demonstrated that depletion of B2 cells instead of B1 cells under anti-CD20 treatment resulted in a slower development and progression of AT. Research on cardiovascular effects of chimeric antiCD20 monoclonal antibody (rituximab, RTX) in RA is definitely of high interest. Use of RTX in a combination with methotrexate does not increase the risk of serious side effects, including CVE, compared with the sole ...Continue Reading

Citations

Jul 18, 2012·Current Rheumatology Reports·Matxalen Amezaga Urruela, Maria E Suarez-Almazor
Feb 4, 2016·Journal of Korean Medical Science·Diana S NovikovaEvgeny L Nasonov
Jul 28, 2016·Terapevticheskiĭ arkhiv·E L NasonovD S Novikova
Aug 28, 2021·International Journal of Molecular Sciences·Anastasia V PoznyakAlexander N Orekhov

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