PMID: 9527031Apr 4, 1998Paper

The effect of antibiotic prophylaxis on the healing of exit sites of peritoneal dialysis catheters in rats

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
R F Pecoits-FilhoH Moore

Abstract

To evaluate the influence of intraperitoneal (i.p.) antibiotic (AB) prophylaxis on the quality of healing and infection rates of exit sites in peritoneal dialysis catheters. Twenty-one Sprague-Dawley rats were dialyzed 3 times per day for 6 weeks. Dianeal solution containing AB was used for all the rats during the first 5 days. The animals were randomized on the sixth day into three groups: group A (AB-free after randomization), group B (AB for 3 weeks), and group C (AB during 6 weeks). Scores were given to each exit site according to the observation. Mean scores from each group were compared in an attempt to find significant differences between the groups. Dialysate and exit-site drainage samples were taken weekly for microbiology. Eight episodes of peritonitis were diagnosed, six in group A and two in group B. The most common bacteria causing peritonitis were gram-negative rods. The mean scores were not significantly different between groups C and B throughout the study, even after the discontinuation of the prophylaxis. Group A, when compared to the other two groups, had significantly higher scores after the second week and throughout the rest of the study. Intraperitoneal antibiotic prophylaxis for 3 weeks after catheter im...Continue Reading

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