PMID: 7088268Apr 1, 1982Paper

The effect of anticonvulsant drugs on convulsions triggered by direct stimulation of the brainstem

P Chiu, W M Burnham


Brainstem-triggered convulsions are generalized convulsive seizures produced by direct electrical stimulation of the mesencephalic reticular formation. Four anticonvulsant drugs, phenobarbital, phenytoin, trimethadione, and ethosuximide, were tested against brainstem-triggered convulsions in the rat using a standard pharmacological dose-response paradigm. All four drugs proved to be active in small, subtoxic doses, producing a response profile similar to that previously reported for maximal pentylenetetrazol seizures. These results appear consistent with the hypotheses that: (1) the brainstem plays an important role in the production of generalized convulsions; and (2) that anticonvulsant drugs exert major therapeutic effects at the brainstem level.


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Jun 1, 1991·The Japanese Journal of Psychiatry and Neurology·T TanakaY Yonemasu
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Sep 22, 2020·British Journal of Anaesthesia·Benjamin F Gruenbaum

Related Concepts

Brain Stem
Dose-Response Relationship, Drug
Electric Stimulation Technique
Potentials, Event-Related
Non-epileptic Convulsion

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