The effect of antidepressants on aversive periaqueductal gray stimulation in rats

European Journal of Pharmacology
F JenckA M Van Delft

Abstract

The selective serotonin (5-HT) uptake inhibitors fluvoxamine and sertraline had anti-aversive effects when administered acutely. Imipramine and clomipramine, which combine noradrenaline (NA) and 5-HT uptake blocking properties, did not have significant effects, whereas the mixed dopamine (DA)/NA uptake blocker nomifensine decreased the thresholds for escape from aversive periaqueductal gray stimulation. These results suggest that indirect 5-HT receptor activation suppresses periaqueductal gray aversion. Conversely, indirect DA and perhaps NA receptor activation appears to enhance periaqueductal gray aversion in rats.

References

Jul 1, 1975·Physiology & Behavior·R S Kiser, R M Lebovitz
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Jan 1, 1994·American Journal of Industrial Medicine·M H KarolM Chan-Yeung

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Citations

Apr 16, 2013·Cell and Tissue Research·Fabrício A MoreiraFrederico G Graeff
Dec 20, 1993·Behavioural Brain Research·F G GraeffR M Oliveira
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·L C SchenbergL C Vargas
Jan 7, 1998·Neuroscience and Biobehavioral Reviews·F G GraeffP O Mora
Nov 1, 1996·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·F JenckJ L Moreau
Aug 26, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·F JenckA M Van Delft
Feb 5, 2002·CNS Drugs·Susan M Cheer, David P Figgitt
Oct 16, 2014·Neuroscience and Biobehavioral Reviews·Luiz Carlos SchenbergJeyce Willig Quintino-Dos-Santos

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