The Effect of Antidepressants on Depression After Traumatic Brain Injury: A Meta-analysis.

The Journal of Head Trauma Rehabilitation
Natalie KreitzerOpeolu Adeoye

Abstract

Following traumatic brain injury (TBI), depressive symptoms are common and may influence recovery. We performed a meta-analysis to estimate the benefit of antidepressants following TBI and compare the estimated effects between antidepressants and placebo. Multiple databases were searched to find prospective pharmacological treatment studies of major depressive disorder (MDD) in adults following TBI. Effect sizes for antidepressant medications in patients with TBI were calculated for within-subjects designs that examined change from baseline after receiving medical treatment and treatment/placebo designs that examined the differences between the antidepressants and placebo groups. A random-effects model was used for both analyses. Of 1028 titles screened, 11 were included. Pooled estimates showed nonsignificant difference in reduction of depression scores between medications and placebo (standardized mean difference of 5 trials = -0.3; 95% CI, -0.6 to 0.0; I = 17%), and a significant reduction in depression scores for individuals after pharmacotherapy (mean change = -11.2; 95% CI, -14.7 to -7.6 on the Hamilton Depression Scale; I = 87%). This meta-analysis found no significant benefit of antidepressant over placebo in the treatm...Continue Reading

References

Jul 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·N BrooksW McKinlay
Apr 1, 1993·Journal of Affective Disorders·R E JorgeF Geisler
Jul 3, 1998·The Journal of Head Trauma Rehabilitation·M R HibbardJ Silver
Sep 23, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·J R FannW J Katon
Jan 12, 2002·Archives of General Psychiatry·Tracey HolsingerBrenda L Plassman
Jun 5, 2003·International Journal of Psychiatry in Medicine·Stefanie A HorsfieldStephen I Deutsch
Jan 7, 2004·Archives of General Psychiatry·Ricardo E JorgeStephan Arndt
Nov 25, 2006·Biological Psychiatry·Ricardo E JorgeVincent Magnotta
Aug 30, 2007·Nature Neuroscience·Keri MartinowichBai Lu
Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chi-Hua ChenEd Bullmore
Jan 23, 2008·Journal of Psychopharmacology·M J RapoportA Feinstein
Mar 26, 2008·The Journal of Head Trauma Rehabilitation·Anbesaw W SelassieClaudia Steiner
Jul 23, 2008·Acta Neurochirurgica. Supplement·A I R MaasUNKNOWN IMPACT Study Group
Aug 14, 2008·JAMA : the Journal of the American Medical Association·Devi E Nampiaparampil
Oct 22, 2008·Archives of Physical Medicine and Rehabilitation·Kathleen Farrell PagulayanSureyya S Dikmen
Nov 27, 2008·The Journal of Head Trauma Rehabilitation·Eduard ZaloshnjaAnbesaw W Selassie
May 2, 2009·Archives of Physical Medicine and Rehabilitation·Teresa A AshmanBrian Greenwald
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jan 7, 2010·JAMA : the Journal of the American Medical Association·Jay C FournierJan Fawcett
Feb 6, 2010·The Journal of Head Trauma Rehabilitation·Ronald T SeelJeffrey S Kreutzer
Feb 12, 2011·Psychiatry Research·Anne HudakRamon Diaz-Arrastia
May 4, 2011·Brain Injury : [BI]·Michael SchönbergerRichard O'Sullivan
Mar 14, 2012·Journal of Psychiatric Research·Bret R RutherfordSteven P Roose
Sep 26, 2012·Human Brain Mapping·Jerome J MallerPaul B Fitzgerald
Oct 6, 2012·The Journal of Neuropsychiatry and Clinical Neurosciences·Vani RaoSusumi Mori
May 16, 2013·Brain Injury : [BI]·Michelle D FaillaAmy K Wagner
Mar 5, 2014·The Journal of Head Trauma Rehabilitation·Shannon B JuengstAmy Kathleen Wagner
Jun 3, 2014·Behavioural Brain Research·Jerome J MallerPaul B Fitzgerald
Jan 22, 2015·JAMA Psychiatry·Jesse R FannUNKNOWN PRISMS Investigators
Oct 20, 2015·The Journal of Head Trauma Rehabilitation·Katherine L SalterRobert W Teasell

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Citations

Jan 15, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·Anya SlowinskiChristopher Byrne
May 13, 2020·Journal of Neurotrauma·Jennifer S AlbrechtVani Rao
Mar 29, 2019·BMC Psychiatry·Noah D Silverberg, William J Panenka
Feb 29, 2020·The Journal of Head Trauma Rehabilitation·Jennifer S AlbrechtVani Rao
Sep 1, 2020·Expert Review of Neurotherapeutics·William D S Killgore
Jan 29, 2019·Frontiers in Neuroscience·Laura B Ngwenya, Steve C Danzer
Nov 10, 2020·Focus : Journal of Life Long Learning in Psychiatry·Susan K ConroyThomas W McAllister
Mar 5, 2021·Reviews in the Neurosciences·Marc FakhouryNada Lawand

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.