The effect of antiviral therapy on serum lipid profiles in chronic hepatitis C

Oncotarget
Batbold BatsaikhanChia-Yen Dai

Abstract

Low lipid profile is associated with hepatitis C virus (HCV) infection. Chronic HCV infection is the main cause of liver injury and serum lipid levels during antiviral treatment. We aimed to evaluate the effect of antiviral treatment on the change of lipid profiles during HCV treatment. Total 863 patients who complete the interferon-based therapy in Kaohsiung Medical University Hospital were included in this study. The lipid profile measured and evaluated in baseline and after 6 months of the treatment. Sustained virological response (SVR) was achieved in 81.2% of all patients. The baseline triglycerides (TG) levels in the SVR group and non SVR groups were similar. The TG levels at 6 months after cessation of the treatment was significantly elevated in SVR group (102.9±57.0 mg/dL, p=0.0001) but did not elevated in non SVR group (94.5±45.6 mg/dL, p=0.690) compared with baseline TG levels. After adjusting patients by four indexes for fibrosis (FIB4) in cut-off point 3.25, serum TG levels significantly increased in low FIB4 group (103.2±57.9 mg/dL, p=0.0001) but not in high FIB4 group (98.1±49.6 mg/dL, p=0.095) after 6 months end of the treatment. Serum TG level was increased greater in patients who had low FIB4 score and patients...Continue Reading

References

Jun 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E ShinoharaY Matsuzawa
Aug 25, 1999·Journal of Medical Virology·H FujieK Koike
Jul 25, 2000·Journal of Hepatology·L Rubbia-BrandtF Negro
Aug 22, 2001·The American Journal of Gastroenterology·M NaeemA M Di Bisceglie
Jan 31, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gabriel PerlemuterChristian Bréchot
Dec 18, 2004·Seminars in Liver Disease·Seela Ramesh, Arun J Sanyal
Feb 26, 2005·Seminars in Liver Disease·Patrice AndréVincent Lotteau
Dec 21, 2005·Journal of Viral Hepatitis·D SiagrisC Labropoulou-Karatza
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kavitha GopalAlbert D Min
Mar 7, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chien-Hung ChenJin-Chuan Sheu
Aug 28, 2007·Nature Cell Biology·Yusuke MiyanariKunitada Shimotohno
Dec 5, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shinichiro TadaToshifumi Hibi
Apr 2, 2009·Journal of Gastroenterology and Hepatology·Ming-Lung Yu, Wan-Long Chuang
Sep 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kathleen E CoreyRaymond T Chung
Sep 15, 2010·The Kaohsiung Journal of Medical Sciences·Jeng-Fu YangWen-Yu Chang
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tatsuya FujinoMunechika Enjoji
Jul 12, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yuan-Hung KuoChuan-Mo Lee
Sep 20, 2011·Gut and Liver·Eun Sun JangSook-Hyang Jeong
Feb 4, 2012·Journal of Hepatology·Elisabetta BugianesiFrancesco Negro
Jul 3, 2013·Journal of Gastroenterology and Hepatology·Chia-Yen DaiHung-Da Tung
Sep 4, 2015·International Journal of Molecular Sciences·Tomohisa NaganoYoshio Aizawa
Nov 13, 2015·BMC Infectious Diseases·Adeel A ButtUNKNOWN ERCHIVES study team
Feb 16, 2016·World Journal of Gastroenterology : WJG·Germana GrassiTonino Alonzi
Sep 30, 2016·World Journal of Gastroenterology : WJG·Arnolfo PetruzzielloCarmela Cacciapuoti
Mar 4, 2015·Clinical Liver Disease·Ming-Lung Yu, Wan-Long Chuang

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Citations

Jul 10, 2020·The Kaohsiung Journal of Medical Sciences·Chung-Feng HuangMing-Lung Yu
Jan 12, 2021·Expert Review of Anti-infective Therapy·Szu-Jen WangMing-Lung Yu
May 4, 2020·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ming-Lung YuWan-Long Chuang
Jun 18, 2021·Frontiers in Medicine·Sergio EstefanMarcia Helena S Costa
Jun 3, 2021·Journal of the Chinese Medical Association : JCMA·Gantsetseg GantumurChia-Yen Dai

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS Statistics

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