The Effect of Aronia Berry on Type 1 Diabetes In Vivo and In Vitro

Journal of Medicinal Food
Yong-Deok JeonJong-Sik Jin

Abstract

The number of diabetic patients worldwide is increasing, and complications such as stroke and cardiovascular disease are becoming a serious cause of death. Diabetes mellitus is classified into two types according to the etiopathogenic mechanism and insulin dependence. Type 1 diabetes (T1D), an insulin-dependent diabetes mellitus, is caused by damage and destruction of pancreatic β cells that produce insulin. It is a disease that is characterized by hyperglycemia and hypoinsulinemia. Aronia berry has been used as a medicinal food in Europe. Aronia contains a variety of ingredients such as polyphenols, anthocyanins, flavonoids, and tannins. Especially, anthocyanin content in aronia berry is known to be much higher than in other plants and berries. It is known for exerting antioxidant, anti-inflammation, and anti-aging effects. Therefore, this study was conducted to investigate the effects of aronia berry extract intake in multiple low-dose streptozotocin (STZ)-induced T1D and to confirm the functional properties of aronia berry. ICR mice (6-week male) were divided into four groups: control (normal control group), STZ (100 mg/kg of STZ-induced T1D group), AR 10 (STZ with oral administration of aronia 10 mg/kg), and AR 100 (STZ wit...Continue Reading

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Citations

Apr 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Man-Xia LuEun-Hee Hwang
Dec 20, 2018·Frontiers in Pharmacology·Rozita NaseriSaeideh Momtaz
Jun 7, 2020·Journal of Physiology and Biochemistry·Francisco LesVíctor López
Mar 11, 2021·Journal of Agricultural and Food Chemistry·Yanwen KongYuehua Wang
Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Akurange Sujeevi Dammadinna WickramasingheAnoja Priyadarshani Attanayake
Nov 19, 2021·Critical Reviews in Food Science and Nutrition·Yao ChenZhiyong He

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Methods Mentioned

BETA
ELISA
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Software Mentioned

Graph Pad Prism
Image Pro Plus
Graph Pad
StepOne

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