PMID: 10674097Feb 16, 2000Paper

The effect of artesunate combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro

Transactions of the Royal Society of Tropical Medicine and Hygiene
Quinton L FivelmanK I Barnes

Abstract

The interactions of artesunate with chloroquine, mefloquine, quinine, doxycycline and pyrimethamine were tested in vitro against chloroquine-sensitive (D10) and chloroquine-resistant (RSA11) strains of Plasmodium falciparum. Mefloquine and quinine both showed synergism of artesunate activity against each of the strains, whilst doxycycline showed an additive interaction. Pyrimethamine combinations were antagonistic, and the combination of artesunate with chloroquine was antagonistic against RSA11, and additive against D10. Although weak antagonism in vitro might not indicate any clinical significance, synergism with artesunate may increase the clinical usefulness of either drug, and could potentially be of value in delaying the emergence of resistance.

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Citations

Dec 31, 2003·Bioorganic & Medicinal Chemistry Letters·Chandan SinghSunil K Puri
Nov 19, 2002·International Journal for Parasitology·Anders Björkman
Oct 3, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·D C Warhurst, M T Duraisingh
Apr 20, 2002·Current Opinion in Infectious Diseases·Peter Perlmann, Anders Björkman
Jun 8, 2011·Antimicrobial Agents and Chemotherapy·Brioni R MooreKevin T Batty
Sep 19, 2007·Antimicrobial Agents and Chemotherapy·Kevin T BattyBrioni R Moore
Jun 25, 2004·Antimicrobial Agents and Chemotherapy·Heinrich C HoppeBrandon W Weber
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·Paul N NewtonNicholas J White
Jan 8, 2011·Journal of Ethnopharmacology·J W GathirwaS A Omar
Jun 6, 2002·Memórias do Instituto Oswaldo Cruz·Ana FerrerasFlor Herrera
Oct 25, 2012·The Journal of Antibiotics·Lissinda H Du PlessisAwie F Kotzé
Feb 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Pooja Rani MinaMahendra P Darokar

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