The effect of arylazido aminopropionyl ATP (ANAPP3) on inhibition of pelvic nerve evoked contractions of the cat urinary bladder

European Journal of Pharmacology
R J Theobald

Abstract

Previously reported work has provided evidence that arylazido aminopropionyl ATP (ANAPP3), a P2-receptor antagonist, blocks the effects of ATP and other purine analogs, in the urinary bladder of the cat. This antagonism appeared limited to those effects mediated by P2-receptors, such as contraction of the urinary bladder. However, it was noted that ANAPP3 did alter the effects of adenosine, mediated through P1-receptors, in some preliminary experiments. A series of experiments was undertaken to determine if ANAPP3 blocks the P1-receptors and/or has effects on inhibition of bladder contractions. The urinary tract of anesthetized cats was exposed by a midline abdominal incision. The pelvic and hypogastric nerves were isolated and prepared for electrical stimulation. Bladder contractions were induced by stimulation of the pelvic nerves every 30 s with square wave pulses. These contractions were inhibited by hypogastric nerves and the exogenous administration of ATP, noradrenaline, adenosine or beta,gamma-methylene ATP (APPCP), a hydrolysis resistant analog of ATP. ANAPP3 (0.5 mumol, i.a.) was administered, but it did not antagonize the inhibition induced by any of the exogenously administered agents or hypogastric nerve stimulatio...Continue Reading

References

Sep 1, 1982·Journal of Autonomic Pharmacology·R J Theobald
Jan 5, 1981·European Journal of Pharmacology·J S FedanD P Westfall

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Citations

Apr 7, 1992·European Journal of Pharmacology·P Sneddon, A McLees
Jul 1, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·H Kontani, K Hayashi
Dec 1, 1993·British Journal of Pharmacology·A U ZiganshinG Burnstock
Sep 26, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Stian Ludvigsen, Lars P Folkow
Sep 22, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·S R NorenL Cornell

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