PMID: 7336126Oct 1, 1981Paper

The effect of ascitic fluid hydrostatic pressure on albumin extravasation rate in patients with cirrhosis of the liver

Scandinavian Journal of Clinical and Laboratory Investigation
J H HenriksenK Winkler

Abstract

Overall transvascular escape rate of albumin [TERalb, i.e. the fraction of intravascular mass of albumin (IVMalb) passing to the extravascular space per unit time] was determined from the disappearance of i.v. injected radioiodinated serum albumin. Patients with tense ascites due to liver cirrhosis and pigs with posthepatic portal hypertension and intraperitoneally instilled fluid were studied before and after abdominal paracentesis in order to evaluate the effect of ascitic fluid hydrostatic pressure on the transvascular escape rate of albumin. TERalb of the ascitic patients (n = 6) were on average 7.8% IVMalb.h-1, which is somewhat higher but not significantly above normal (mean 5.6% IVMalb.h-1). After paracentesis and removal of the ascitic fluid, TERalb rose significantly to an average of 11.9% IVMalb.h-1 (P less than 0.05). The fraction of IVMalb passing into the peritoneal cavity was on average 0.21 and 0.38% IVMalb.h-1 before and after paracentesis, respectively (n = 4). In ascitic, posthepatic portal-hypertensive pigs (n = 6), TERalb averaged 15.1% IVMalb.h-1, a value not being significantly different from non-ascitic, normotensive controls (mean 16.1% IVMalb.h-1). After paracentesis, TERalb rose significantly to an ave...Continue Reading

References

Sep 1, 1979·Circulation Research·G A LaineJ Granger
Nov 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation·H H ParvingN A Lassen
Jan 1, 1977·Scandinavian Journal of Gastroenterology·J H Henriksen, K Winkler
Dec 11, 1975·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·G SzaboF Jakab
May 1, 1973·Circulation Research·H P Parving, F Gyntelberg
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T DoumasH G Biggs
Apr 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·J H HenriksenK Winkler
Oct 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·J H HenriksenK Winkler
Oct 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·J H HenriksenK Winkler
Aug 1, 1967·The Journal of Clinical Investigation·F L Lieberman, T B Reynolds

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Citations

Mar 29, 2012·BMC Gastroenterology·David G Levitt, Michael D Levitt
Oct 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·J H Henriksen, P Schlichting
Apr 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·J H Henriksen, H Ring-Larsen

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