PMID: 11901464Mar 20, 2002Paper

The effect of aspirin and prostaglandin E(1) on the patency of microvascular anastomosis in the rats

Hand Surgery : an International Journal Devoted to Hand and Upper Limb Surgery and Related Research : Journal of the Asia-Pacific Federation of Societies for Surgery of the Hand
K S LeeS J Cho

Abstract

The purpose of this study was to evaluate the effect of oral prostaglandin E(1)(PGE(1)) on the patency of the microvascular anastomosis of the carotid artery in rat. A total of 48 rats were used, and divided into three groups. The first group (A) was used as a control with no medical agent being used after anastomosis, the second group (B) was medicated with aspirin, and the third group (C) was medicated with oral PGE(1). In each group, four rats were sacrificed serially on every post-operative 3, 5, 10 and 15 days after arterial anastomosis. Patency and histologic evaluations at the anastomotic site were observed. The results revealed that the PGE(1) therapied group showed highest patency rate (100%), lesser formation of mural thrombosis, and also minimal changes in the intimal hyperplasia and medial fibrosis. From these findings, we could conclude that PGE(1) has superior effect on maintaining the patency after microvascular surgery.

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Citations

Jul 22, 2010·Annales de chirurgie plastique et esthétique·L-A DumontI Garrido-Stowhas
Mar 20, 2010·Chirurgie de la main·L-A DumontUNKNOWN Fédération européenne des services d'urgence mains (Fesum)
May 28, 2011·Microsurgery·Masayuki OkochiAkiyoshi Kajikawa
Jun 9, 2006·Microsurgery·Hung-Chi ChenStefano Spanio
Feb 18, 2021·Journal of Plastic Surgery and Hand Surgery·Mehmet İhsan Okurİbrahim Özercan

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