The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats

European Journal of Pharmacology
S O Fagbemi

Abstract

The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats. Their effect were very pronounced on ventricular ectopic activity occurring between the sixteenth and thirtieth min. These effects suggest the desirability of combining the non steroidal anti-inflammatory drugs with beta-adrenergic blockers in the treatment of ventricular arrhythmias following acute myocardial infarction.

References

Jun 1, 1975·The Journal of Clinical Investigation·R W AlexanderT Cooper
Dec 1, 1972·The American Journal of Cardiology·J I HaftR Oestreicher
Jul 1, 1967·The Journal of Pathology and Bacteriology·B J Northover
Nov 5, 1981·European Journal of Pharmacology·O Fagbemi, J R Parratt
Dec 1, 1980·Circulation·P C Elwood, P M Sweetnam

Citations

Jan 1, 1985·Molecular Aspects of Medicine·J H BottingM J Walker
Apr 1, 1988·British Journal of Pharmacology·R M Tripathi, R Kaushal
Sep 3, 2013·Circulation. Arrhythmia and Electrophysiology·Tarvinder S DhanjalM J Curtis
Jul 1, 1996·Molecular and Cellular Biochemistry·M AradB Rabinowitz

Related Concepts

Metazoa
Anti-Inflammatory Agents
Cardiac Arrhythmia
Micristin
Sinus Node Artery
Hemodynamics
Osmosin
Ligature
Meclomen
August Rats

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